Juvenis Scientia (Dec 2021)

COVID-19 AND CANCER COMORBIDITY: THERAPEUTIC OPPORTUNITIES AND CHALLENGES (RUSSIAN TRANSLATION)

  • A. S. Pathania,
  • P. Prathipati,
  • B. A. A. Abdul,
  • S. Chava,
  • S. S. Katta,
  • S. C. Gupta,
  • P. R. Gangula,
  • M. K. Pandey,
  • D. L. Durden,
  • S. N. Byrareddy,
  • K. B. Challagundla

DOI
https://doi.org/10.32415/jscientia_2021_7_6_28-70
Journal volume & issue
Vol. 7, no. 6
pp. 28 – 70

Abstract

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The coronavirus disease 2019 (COVID-19) is a viral disease caused by a novel severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) that affects the respiratory system of infected individuals. COVID-19 spreads between humans through respiratory droplets produced when an infected person coughs or sneezes. The COVID-19 outbreak originated in Wuhan, China at the end of 2019. As of 29 Sept 2020, over 235 countries, areas or territories across the globe reported a total of 33,441,919 confirmed cases, and 1,003,497 confirmed deaths due to COVID-19. Individuals of all ages are at risk for infection, but in most cases disease severity is associated with age and pre- existing diseases that compromise immunity, like cancer. Numerous reports suggest that people with cancer can be at higher risk of severe illness and related deaths from COVID-19. Therefore, managing cancer care under this pandemic is challenging and requires a collaborative multidisciplinary approach for optimal care of cancer patients in hospital settings. In this comprehensive review, we discuss the impact of the COVID-19 pandemic on cancer patients, their care, and treatment. Further, this review covers the SARS-CoV-2 pandemic, genome characterization, COVID-19 pathophysiology, and associated signaling pathways in cancer, and the choice of anticancer agents as repurposed drugs for treating COVID-19. Original article: Pathania AS, Prathipati P, Abdul BAA, et al. COVID-19 and Cancer Comorbidity: Therapeutic Opportunities and Challenges. Theranostics. 2021;11(2):731-753. DOI: 10.7150/thno.51471. The article was translated into Russian and published under the terms of the Creative Commons Attribution 4.0 license.

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