Nature Communications (Jun 2016)
A rhesus macaque model of Asian-lineage Zika virus infection
- Dawn M. Dudley,
- Matthew T. Aliota,
- Emma L. Mohr,
- Andrea M. Weiler,
- Gabrielle Lehrer-Brey,
- Kim L. Weisgrau,
- Mariel S. Mohns,
- Meghan E. Breitbach,
- Mustafa N. Rasheed,
- Christina M. Newman,
- Dane D. Gellerup,
- Louise H. Moncla,
- Jennifer Post,
- Nancy Schultz-Darken,
- Michele L. Schotzko,
- Jennifer M. Hayes,
- Josh A. Eudailey,
- M. Anthony Moody,
- Sallie R. Permar,
- Shelby L. O’Connor,
- Eva G. Rakasz,
- Heather A. Simmons,
- Saverio Capuano,
- Thaddeus G. Golos,
- Jorge E. Osorio,
- Thomas C. Friedrich,
- David H. O’Connor
Affiliations
- Dawn M. Dudley
- Department of Pathology and Laboratory Medicine, University of Wisconsin-Madison
- Matthew T. Aliota
- Department of Pathobiological Sciences, University of Wisconsin-Madison
- Emma L. Mohr
- Department of Pediatrics, School of Medicine and Public Health, University of Wisconsin-Madison
- Andrea M. Weiler
- Wisconsin National Primate Research Center, University of Wisconsin-Madison
- Gabrielle Lehrer-Brey
- Wisconsin National Primate Research Center, University of Wisconsin-Madison
- Kim L. Weisgrau
- Wisconsin National Primate Research Center, University of Wisconsin-Madison
- Mariel S. Mohns
- Department of Pathology and Laboratory Medicine, University of Wisconsin-Madison
- Meghan E. Breitbach
- Department of Pathology and Laboratory Medicine, University of Wisconsin-Madison
- Mustafa N. Rasheed
- Department of Pathology and Laboratory Medicine, University of Wisconsin-Madison
- Christina M. Newman
- Department of Pathology and Laboratory Medicine, University of Wisconsin-Madison
- Dane D. Gellerup
- Wisconsin National Primate Research Center, University of Wisconsin-Madison
- Louise H. Moncla
- Department of Pathology and Laboratory Medicine, University of Wisconsin-Madison
- Jennifer Post
- Wisconsin National Primate Research Center, University of Wisconsin-Madison
- Nancy Schultz-Darken
- Wisconsin National Primate Research Center, University of Wisconsin-Madison
- Michele L. Schotzko
- Wisconsin National Primate Research Center, University of Wisconsin-Madison
- Jennifer M. Hayes
- Wisconsin National Primate Research Center, University of Wisconsin-Madison
- Josh A. Eudailey
- Department of Pediatrics and Human Vaccine Institute, Duke University Medical Center
- M. Anthony Moody
- Department of Pediatrics and Human Vaccine Institute, Duke University Medical Center
- Sallie R. Permar
- Department of Pediatrics and Human Vaccine Institute, Duke University Medical Center
- Shelby L. O’Connor
- Department of Pathology and Laboratory Medicine, University of Wisconsin-Madison
- Eva G. Rakasz
- Wisconsin National Primate Research Center, University of Wisconsin-Madison
- Heather A. Simmons
- Wisconsin National Primate Research Center, University of Wisconsin-Madison
- Saverio Capuano
- Wisconsin National Primate Research Center, University of Wisconsin-Madison
- Thaddeus G. Golos
- Wisconsin National Primate Research Center, University of Wisconsin-Madison
- Jorge E. Osorio
- Department of Pathobiological Sciences, University of Wisconsin-Madison
- Thomas C. Friedrich
- Department of Pathobiological Sciences, University of Wisconsin-Madison
- David H. O’Connor
- Department of Pathology and Laboratory Medicine, University of Wisconsin-Madison
- DOI
- https://doi.org/10.1038/ncomms12204
- Journal volume & issue
-
Vol. 7,
no. 1
pp. 1 – 9
Abstract
Animal models of infection with Zika virus (ZIKV) are urgently needed for a better understanding of pathogenesis and for testing potential therapies. Here, the authors describe infection of rhesus macaques with an Asian-lineage ZIKV strain as a relevant animal model for studying ZIKV pathogenesis.
