Nature Communications (Dec 2019)
Mutant p53 drives clonal hematopoiesis through modulating epigenetic pathway
- Sisi Chen,
- Qiang Wang,
- Hao Yu,
- Maegan L. Capitano,
- Sasidhar Vemula,
- Sarah C. Nabinger,
- Rui Gao,
- Chonghua Yao,
- Michihiro Kobayashi,
- Zhuangzhuang Geng,
- Aidan Fahey,
- Danielle Henley,
- Stephen Z. Liu,
- Sergio Barajas,
- Wenjie Cai,
- Eric R. Wolf,
- Baskar Ramdas,
- Zhigang Cai,
- Hongyu Gao,
- Na Luo,
- Yang Sun,
- Terrence N. Wong,
- Daniel C. Link,
- Yunlong Liu,
- H. Scott Boswell,
- Lindsey D. Mayo,
- Gang Huang,
- Reuben Kapur,
- Mervin C. Yoder,
- Hal E. Broxmeyer,
- Zhonghua Gao,
- Yan Liu
Affiliations
- Sisi Chen
- Department of Biochemistry and Molecular Biology, Indiana University
- Qiang Wang
- Department of Biochemistry and Molecular Biology, the Cancer Institute, College of Medicine, Pennsylvania State University
- Hao Yu
- Department of Pediatrics, Herman B Wells Center for Pediatric Research, Indiana University
- Maegan L. Capitano
- Department of Microbiology and Immunology, Indiana University
- Sasidhar Vemula
- Department of Pediatrics, Herman B Wells Center for Pediatric Research, Indiana University
- Sarah C. Nabinger
- Department of Pediatrics, Herman B Wells Center for Pediatric Research, Indiana University
- Rui Gao
- Department of Pediatrics, Herman B Wells Center for Pediatric Research, Indiana University
- Chonghua Yao
- Department of Pediatrics, Herman B Wells Center for Pediatric Research, Indiana University
- Michihiro Kobayashi
- Department of Pediatrics, Herman B Wells Center for Pediatric Research, Indiana University
- Zhuangzhuang Geng
- Department of Biochemistry and Molecular Biology, the Cancer Institute, College of Medicine, Pennsylvania State University
- Aidan Fahey
- Department of Pediatrics, Herman B Wells Center for Pediatric Research, Indiana University
- Danielle Henley
- Department of Pediatrics, Herman B Wells Center for Pediatric Research, Indiana University
- Stephen Z. Liu
- Department of Medical Genetics, Indiana University
- Sergio Barajas
- Department of Biochemistry and Molecular Biology, Indiana University
- Wenjie Cai
- Department of Biochemistry and Molecular Biology, Indiana University
- Eric R. Wolf
- Department of Pediatrics, Herman B Wells Center for Pediatric Research, Indiana University
- Baskar Ramdas
- Department of Pediatrics, Herman B Wells Center for Pediatric Research, Indiana University
- Zhigang Cai
- Department of Pediatrics, Herman B Wells Center for Pediatric Research, Indiana University
- Hongyu Gao
- Department of Medical Genetics, Indiana University
- Na Luo
- Department of Ophthalmology, Indiana University
- Yang Sun
- Department of Ophthalmology, Indiana University
- Terrence N. Wong
- Siteman Cancer Center, Washington University
- Daniel C. Link
- Siteman Cancer Center, Washington University
- Yunlong Liu
- Department of Medical Genetics, Indiana University
- H. Scott Boswell
- Department of Medicine, Indiana University
- Lindsey D. Mayo
- Department of Pediatrics, Herman B Wells Center for Pediatric Research, Indiana University
- Gang Huang
- Division of Pathology and Experimental Hematology and Cancer Biology, Cincinnati Children’s Hospital Medical Center
- Reuben Kapur
- Department of Pediatrics, Herman B Wells Center for Pediatric Research, Indiana University
- Mervin C. Yoder
- Department of Pediatrics, Herman B Wells Center for Pediatric Research, Indiana University
- Hal E. Broxmeyer
- Department of Microbiology and Immunology, Indiana University
- Zhonghua Gao
- Department of Biochemistry and Molecular Biology, the Cancer Institute, College of Medicine, Pennsylvania State University
- Yan Liu
- Department of Biochemistry and Molecular Biology, Indiana University
- DOI
- https://doi.org/10.1038/s41467-019-13542-2
- Journal volume & issue
-
Vol. 10,
no. 1
pp. 1 – 14
Abstract
Ageing is associated with clonal hematopoiesis of indeterminate potential (CHIP), which is linked to increased risks of hematological malignancies. Here the authors uncover an epigenetic mechanism through which mutant p53 drives clonal hematopoiesis through interaction with EZH2.
