The iron-dependent repressor YtgR is a tryptophan-dependent attenuator of the trpRBA operon in Chlamydia trachomatis

Nick D. Pokorzynski; Nathan D. Hatch; Scot P. Ouellette; Rey A. Carabeo

doi:10.1038/s41467-020-20181-5

Nature Communications (Dec 2020)

The iron-dependent repressor YtgR is a tryptophan-dependent attenuator of the trpRBA operon in Chlamydia trachomatis

Nick D. Pokorzynski,
Nathan D. Hatch,
Scot P. Ouellette,
Rey A. Carabeo

Affiliations

Nick D. Pokorzynski: School of Molecular Biosciences, College of Veterinary Medicine, Washington State University
Nathan D. Hatch: Department of Pathology and Microbiology, University of Nebraska Medical Center
Scot P. Ouellette: Department of Pathology and Microbiology, University of Nebraska Medical Center
Rey A. Carabeo: Department of Pathology and Microbiology, University of Nebraska Medical Center

DOI: https://doi.org/10.1038/s41467-020-20181-5
Journal volume & issue: Vol. 11, no. 1
pp. 1 – 15

Abstract

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Chlamydia trachomatis does not possess TrpL-mediated transcription attenuation of its trp operon. Here, the authors show that an iron-dependent regulator, YtgR, acts as a tryptophan-dependent attenuator of the trp operon in this organism, due to translational regulation of YtgR levels via a triple tryptophan motif.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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