Investigating increasingly complex macromolecular systems with small-angle X-ray scattering

Abstract

The biological solution small-angle X-ray scattering (BioSAXS) field has undergone tremendous development over recent decades. This means that increasingly complex biological questions can be addressed by the method. An intricate synergy between advances in hardware and software development, data collection and evaluation strategies and implementations that readily allow integration with complementary techniques result in significant results and a rapidly growing user community with ever increasing ambitions. Here, a review of these developments, by including a selection of novel BioSAXS methodologies and recent results, is given.

Keywords

• biological solution small-angle X-ray scattering (BioSAXS)
• synchrotron radiation
• beamlines
• structural complexity
• biostructural research