Optical coherence tomography in myelin-oligodendrocyte-glycoprotein antibody-seropositive patients: a longitudinal study

Frederike C. Oertel; Olivier Outteryck; Benjamin Knier; Hanna Zimmermann; Nadja Borisow; Judith Bellmann-Strobl; Astrid Blaschek; Sven Jarius; Markus Reindl; Klemens Ruprecht; Edgar Meinl; Reinhard Hohlfeld; Friedemann Paul; Alexander U. Brandt; Tania Kümpfel; Joachim Havla

doi:10.1186/s12974-019-1521-5

Journal of Neuroinflammation (Jul 2019)

Optical coherence tomography in myelin-oligodendrocyte-glycoprotein antibody-seropositive patients: a longitudinal study

Frederike C. Oertel,
Olivier Outteryck,
Benjamin Knier,
Hanna Zimmermann,
Nadja Borisow,
Judith Bellmann-Strobl,
Astrid Blaschek,
Sven Jarius,
Markus Reindl,
Klemens Ruprecht,
Edgar Meinl,
Reinhard Hohlfeld,
Friedemann Paul,
Alexander U. Brandt,
Tania Kümpfel,
Joachim Havla

Affiliations

Frederike C. Oertel: Experimental and Clinical Research Center, Max Delbrueck Center for Molecular Medicine and Charité – Universitätsmedizin Berlin, Freie Universität Berlin, Humboldt-Universität zu Berlin and Berlin Institute of Health
Olivier Outteryck: Department of Neurology and Neuroradiology, Roger Salengro Hospital, University of Lille, INSERM 1171
Benjamin Knier: Department of Neurology, Klinikum Rechts der Isar, Technische Universität München
Hanna Zimmermann: Experimental and Clinical Research Center, Max Delbrueck Center for Molecular Medicine and Charité – Universitätsmedizin Berlin, Freie Universität Berlin, Humboldt-Universität zu Berlin and Berlin Institute of Health
Nadja Borisow: Experimental and Clinical Research Center, Max Delbrueck Center for Molecular Medicine and Charité – Universitätsmedizin Berlin, Freie Universität Berlin, Humboldt-Universität zu Berlin and Berlin Institute of Health
Judith Bellmann-Strobl: Experimental and Clinical Research Center, Max Delbrueck Center for Molecular Medicine and Charité – Universitätsmedizin Berlin, Freie Universität Berlin, Humboldt-Universität zu Berlin and Berlin Institute of Health
Astrid Blaschek: Department of Pediatric Neurology and Developmental Medicine, Dr. von Hauner’s Children’s Hospital, University of Munich
Sven Jarius: Molecular Neuroimmunology Group, Department of Neurology, University of Heidelberg
Markus Reindl: Clinical Department of Neurology, Medical University of Innsbruck
Klemens Ruprecht: Department of Neurology, Charité – Universitätsmedizin Berlin, Freie Universität Berlin, Humboldt-Universität zu Berlin and Berlin, Institute of Health
Edgar Meinl: Institute of Clinical Neuroimmunology, Ludwig-Maximilians University
Reinhard Hohlfeld: Munich Cluster for Systems Neurology
Friedemann Paul: Experimental and Clinical Research Center, Max Delbrueck Center for Molecular Medicine and Charité – Universitätsmedizin Berlin, Freie Universität Berlin, Humboldt-Universität zu Berlin and Berlin Institute of Health
Alexander U. Brandt: Experimental and Clinical Research Center, Max Delbrueck Center for Molecular Medicine and Charité – Universitätsmedizin Berlin, Freie Universität Berlin, Humboldt-Universität zu Berlin and Berlin Institute of Health
Tania Kümpfel: Institute of Clinical Neuroimmunology, Ludwig-Maximilians University
Joachim Havla: Institute of Clinical Neuroimmunology, Ludwig-Maximilians University

DOI: https://doi.org/10.1186/s12974-019-1521-5
Journal volume & issue: Vol. 16, no. 1
pp. 1 – 9

Abstract

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Abstract Background Serum antibodies against myelin-oligodendrocyte-glycoprotein (MOG-IgG) are detectable in a proportion of patients with acute or relapsing neuroinflammation. It is unclear, if neuro-axonal damage occurs only in an attack-dependent manner or also progressively. Therefore, this study aimed to investigate longitudinally intra-retinal layer changes in eyes without new optic neuritis (ON) in MOG-IgG-seropositive patients. Methods We included 38 eyes of 24 patients without ON during follow-up (F/U) [median years (IQR)] 1.9 (1.0–2.2) and 56 eyes of 28 age- and sex-matched healthy controls (HC). The patient group’s eyes included 18 eyes without (EyeON-) and 20 eyes with history of ON (EyeON+). Using spectral domain optical coherence tomography (OCT), we acquired peripapillary retinal nerve fiber layer thickness (pRNFL) and volumes of combined ganglion cell and inner plexiform layer (GCIP), inner nuclear layer (INL), and macular volume (MV). High-contrast visual acuity (VA) was assessed at baseline. Results At baseline in EyeON-, pRNFL (94.3 ± 15.9 μm, p = 0.36), INL (0.26 ± 0.03 mm3, p = 0.11), and MV (2.34 ± 0.11 mm3, p = 0.29) were not reduced compared to HC; GCIP showed thinning (0.57 ± 0.07 mm3; p = 0.008), and VA was reduced (logMAR 0.05 ± 0.15 vs. − 0.09 ± 0.14, p = 0.008) in comparison to HC. Longitudinally, we observed pRNFL thinning in models including all patient eyes (annual reduction − 2.20 ± 4.29 μm vs. − 0.35 ± 1.17 μm, p = 0.009) in comparison to HC. Twelve EyeON- with other than ipsilateral ON attacks ≤ 6 months before baseline showed thicker pRNFL at baseline and more severe pRNFL thinning in comparison to 6 EyeON- without other clinical relapses. Conclusions We observed pRNFL thinning in patients with MOG-IgG during F/U, which was not accompanied by progressive GCIP reduction. This effect could be caused by a small number of EyeON- with other than ipsilateral ON attacks within 6 months before baseline. One possible interpretation could be a reduction of the swelling, which could mean that MOG-IgG patients show immune-related swelling in the CNS also outside of an attack’s target area.

Published in Journal of Neuroinflammation

ISSN: 1742-2094 (Online)
Publisher: BMC
Country of publisher: United Kingdom
LCC subjects: Medicine: Internal medicine: Neurosciences. Biological psychiatry. Neuropsychiatry: Neurology. Diseases of the nervous system
Website: https://jneuroinflammation.biomedcentral.com/

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