The Aging Male (Dec 2022)

Reduced sleep duration increases the risk of lower urinary tract symptoms suggestive of benign prostatic hyperplasia in middle-aged and elderly males: a national cross-sectional study

  • Yang Xiong,
  • Yangchang Zhang,
  • Fuxun Zhang,
  • Changjing Wu,
  • Feng Qin,
  • Jiuhong Yuan

DOI
https://doi.org/10.1080/13685538.2022.2079627
Journal volume & issue
Vol. 25, no. 1
pp. 159 – 166

Abstract

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Background The prevalence of lower urinary tract symptoms suggestive of benign prostatic hyperplasia (LUTS/BPH) remains high in men. However, whether reduced sleep duration enhances the risk of LUTS/BPH remains unknown. Materials and methods The 2015 China Health and Retirement Longitudinal Study was used in this study. Binary logistic regression was adopted to test the relationship between sleep duration and LUTS/BPH. Restricted cubic spline (RCS) regression was used to examine the non-linear association. In sensitivity analyses, propensity scores matching was performed to verify the robustness of the results. Results In this study, 8,920 males aged 40 years above were enrolled. In the fully adjusted logistic model, across the quartiles of sleep duration, the odds ratios of LUTS/BPH were 1.00 (reference), 0.94 (95% CI 0.77–1.15), 0.74 (95% CI 0.58–0.94), 0.54 (0.37–0.75), respectively. The results of RCS indicated a non-linear inverted U-shaped association between sleep duration and LUTS/BPH (p for non-linearity 0.05). Conclusion Reduced sleep duration is significantly associated with the increases of the LUTS/BPH risk in Chinese middle-aged and elderly males.

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