Incidence of Hospitalisation and Emergency Department Visits for Pneumococcal Disease in Children, Adolescents, and Adults in Liguria, Italy: A Retrospective Analysis from 2012–2018
Matteo Astengo,
Chiara Paganino,
Daniela Amicizia,
Laura Sticchi,
Andrea Orsi,
Giancarlo Icardi,
Maria Francesca Piazza,
Salini Mohanty,
Francesca Senese,
Gian Marco Prandi,
Filippo Ansaldi
Affiliations
Matteo Astengo
Regional Health Agency of Liguria (ALiSa), Piazza della Vittoria 15, 16121 Genoa, Italy
Chiara Paganino
Regional Health Agency of Liguria (ALiSa), Piazza della Vittoria 15, 16121 Genoa, Italy
Daniela Amicizia
Regional Health Agency of Liguria (ALiSa), Piazza della Vittoria 15, 16121 Genoa, Italy
Laura Sticchi
Department of Health’s Science (DiSSal), University of Genoa, 16132 Genoa, Italy
Andrea Orsi
Department of Health’s Science (DiSSal), University of Genoa, 16132 Genoa, Italy
Giancarlo Icardi
Department of Health’s Science (DiSSal), University of Genoa, 16132 Genoa, Italy
Maria Francesca Piazza
Regional Health Agency of Liguria (ALiSa), Piazza della Vittoria 15, 16121 Genoa, Italy
Salini Mohanty
Merck & Co., Inc., 126 East Lincoln Ave., P.O. Box 2000, Rahway, NJ 07065, USA
Francesca Senese
MSD Italy, Via Vitorchiano 151, 00189 Rome, Italy
Gian Marco Prandi
MSD Italy, Via Vitorchiano 151, 00189 Rome, Italy
Filippo Ansaldi
Regional Health Agency of Liguria (ALiSa), Piazza della Vittoria 15, 16121 Genoa, Italy
Streptococcus pneumoniae infection is responsible for significant morbidity and mortality, particularly in young children and older adults. The aim of this study was to investigate the incidence of hospitalisation and emergency department (ED) visits in relation to episodes of pneumococcal disease (PD) following the introduction of pneumococcal conjugate vaccines (PCVs) into the Liguria region of Italy. Between 2012 and 2018, episodes of all-cause pneumonia (80,152), pneumococcal-specific pneumonia (1254), unspecified pneumonia (66,293), acute otitis media (AOM; 17,040), and invasive PD (IPD; 1788) were identified from in-patient claims, ED and hospital discharge records, and the Liguria Chronic Condition Data Warehouse. In children p p < 0.001). Pneumococcal and unspecified pneumonia hospital admissions increased significantly during the study period, considerably affecting those ≥ 65 years of age. IPD hospitalisations varied across all age groups, but a significant change was not observed. Despite pneumococcal vaccination, substantial burden remains for PD in children and adults in Liguria, Italy.
