Structure and evolvement of Spirulina platensis Fe-SOD(钝顶螺旋藻Fe-SOD的结构与进化)

LUMin(卢敏); QINGui-xiang(秦桂香); GONGXing-guo(龚兴国); GUOJian-jun(郭建军); ZHONGWen-tao(钟文涛)

doi:zjup/1008-9497.2005.32.4.442-447

Zhejiang Daxue xuebao. Lixue ban (Jul 2005)

Structure and evolvement of Spirulina platensis Fe-SOD(钝顶螺旋藻Fe-SOD的结构与进化)

LUMin(卢敏),
QINGui-xiang(秦桂香),
GONGXing-guo(龚兴国),
GUOJian-jun(郭建军),
ZHONGWen-tao(钟文涛)

Affiliations

LUMin(卢敏): Institute of Bio-macromolecule and Enzymatic Engineering, Zhejiang University, Hangzhou 310027, China(浙江大学生物大分子与酶工程研究所，浙江杭州 310027)
QINGui-xiang(秦桂香): Institute of Bio-macromolecule and Enzymatic Engineering, Zhejiang University, Hangzhou 310027, China(浙江大学生物大分子与酶工程研究所，浙江杭州 310027)
GONGXing-guo(龚兴国)
GUOJian-jun(郭建军): Institute of Bio-macromolecule and Enzymatic Engineering, Zhejiang University, Hangzhou 310027, China(浙江大学生物大分子与酶工程研究所，浙江杭州 310027)
ZHONGWen-tao(钟文涛): Institute of Bio-macromolecule and Enzymatic Engineering, Zhejiang University, Hangzhou 310027, China(浙江大学生物大分子与酶工程研究所，浙江杭州 310027)

DOI
Journal volume & issue: Vol. 32, no. 4
pp. 442 – 447

Abstract

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超氧化物歧化酶（Superoxide dismutase，SOD）是一类重要的具有抗氧化损伤功能的金属酶.利用生物信息学手段，分析了钝顶螺旋藻(Spirulina platensis)Fe-SOD的结构与进化，结合此蛋白的功能，揭示了两者的内在联系：在结构上，此蛋白的中间区城(26 AA~160 AA）结构紧凑，为酶的活性中心，两端区域离活性中心较远；在进化上，此蛋白两端区域较中间区域更倾向于发生突变.并且通过Fe-SOD，首次对以上三者间特殊关系的形成机制进行了猜想与假设.

Published in Zhejiang Daxue xuebao. Lixue ban

ISSN: 1008-9497 (Print)
Publisher: Zhejiang University Press
Country of publisher: China
LCC subjects: Science: Mathematics: Instruments and machines: Electronic computers. Computer science; Science: Physics
Website: https://www.zjujournals.com/sci/EN/1008-9497/home.shtml

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