Nature Communications (Jun 2020)
Bone marrow adipose tissue is a unique adipose subtype with distinct roles in glucose homeostasis
- Karla J. Suchacki,
- Adriana A. S. Tavares,
- Domenico Mattiucci,
- Erica L. Scheller,
- Giorgos Papanastasiou,
- Calum Gray,
- Matthew C. Sinton,
- Lynne E. Ramage,
- Wendy A. McDougald,
- Andrea Lovdel,
- Richard J. Sulston,
- Benjamin J. Thomas,
- Bonnie M. Nicholson,
- Amanda J. Drake,
- Carlos J. Alcaide-Corral,
- Diana Said,
- Antonella Poloni,
- Saverio Cinti,
- Gavin J. Macpherson,
- Marc R. Dweck,
- Jack P. M. Andrews,
- Michelle C. Williams,
- Robert J. Wallace,
- Edwin J. R. van Beek,
- Ormond A. MacDougald,
- Nicholas M. Morton,
- Roland H. Stimson,
- William P. Cawthorn
Affiliations
- Karla J. Suchacki
- University/BHF Centre for Cardiovascular Science, University of Edinburgh, The Queen’s Medical Research Institute, Edinburgh BioQuarter
- Adriana A. S. Tavares
- University/BHF Centre for Cardiovascular Science, University of Edinburgh, The Queen’s Medical Research Institute, Edinburgh BioQuarter
- Domenico Mattiucci
- University/BHF Centre for Cardiovascular Science, University of Edinburgh, The Queen’s Medical Research Institute, Edinburgh BioQuarter
- Erica L. Scheller
- Division of Bone and Mineral Diseases, Department of Medicine, Washington University
- Giorgos Papanastasiou
- Edinburgh Imaging, University of Edinburgh
- Calum Gray
- Edinburgh Imaging, University of Edinburgh
- Matthew C. Sinton
- University/BHF Centre for Cardiovascular Science, University of Edinburgh, The Queen’s Medical Research Institute, Edinburgh BioQuarter
- Lynne E. Ramage
- University/BHF Centre for Cardiovascular Science, University of Edinburgh, The Queen’s Medical Research Institute, Edinburgh BioQuarter
- Wendy A. McDougald
- University/BHF Centre for Cardiovascular Science, University of Edinburgh, The Queen’s Medical Research Institute, Edinburgh BioQuarter
- Andrea Lovdel
- University/BHF Centre for Cardiovascular Science, University of Edinburgh, The Queen’s Medical Research Institute, Edinburgh BioQuarter
- Richard J. Sulston
- University/BHF Centre for Cardiovascular Science, University of Edinburgh, The Queen’s Medical Research Institute, Edinburgh BioQuarter
- Benjamin J. Thomas
- University/BHF Centre for Cardiovascular Science, University of Edinburgh, The Queen’s Medical Research Institute, Edinburgh BioQuarter
- Bonnie M. Nicholson
- University/BHF Centre for Cardiovascular Science, University of Edinburgh, The Queen’s Medical Research Institute, Edinburgh BioQuarter
- Amanda J. Drake
- University/BHF Centre for Cardiovascular Science, University of Edinburgh, The Queen’s Medical Research Institute, Edinburgh BioQuarter
- Carlos J. Alcaide-Corral
- University/BHF Centre for Cardiovascular Science, University of Edinburgh, The Queen’s Medical Research Institute, Edinburgh BioQuarter
- Diana Said
- University/BHF Centre for Cardiovascular Science, University of Edinburgh, The Queen’s Medical Research Institute, Edinburgh BioQuarter
- Antonella Poloni
- Dipartimento di Scienze Cliniche e Molecolari, Clinica di Ematologia, Università Politecnica delle Marche
- Saverio Cinti
- Dipartimento di Scienze Cliniche e Molecolari, Clinica di Ematologia, Università Politecnica delle Marche
- Gavin J. Macpherson
- Department of Orthopaedic Surgery, Royal Infirmary of Edinburgh
- Marc R. Dweck
- University/BHF Centre for Cardiovascular Science, University of Edinburgh, The Queen’s Medical Research Institute, Edinburgh BioQuarter
- Jack P. M. Andrews
- University/BHF Centre for Cardiovascular Science, University of Edinburgh, The Queen’s Medical Research Institute, Edinburgh BioQuarter
- Michelle C. Williams
- University/BHF Centre for Cardiovascular Science, University of Edinburgh, The Queen’s Medical Research Institute, Edinburgh BioQuarter
- Robert J. Wallace
- Department of Orthopaedics, The University of Edinburgh
- Edwin J. R. van Beek
- Edinburgh Imaging, University of Edinburgh
- Ormond A. MacDougald
- Department of Molecular & Integrative Physiology, University of Michigan
- Nicholas M. Morton
- University/BHF Centre for Cardiovascular Science, University of Edinburgh, The Queen’s Medical Research Institute, Edinburgh BioQuarter
- Roland H. Stimson
- University/BHF Centre for Cardiovascular Science, University of Edinburgh, The Queen’s Medical Research Institute, Edinburgh BioQuarter
- William P. Cawthorn
- University/BHF Centre for Cardiovascular Science, University of Edinburgh, The Queen’s Medical Research Institute, Edinburgh BioQuarter
- DOI
- https://doi.org/10.1038/s41467-020-16878-2
- Journal volume & issue
-
Vol. 11,
no. 1
pp. 1 – 18
Abstract
Bone marrow adipose tissue (BMAT) comprises over 10% of total fat mass but its systemic metabolic role is unclear. Here, the authors show that BMAT glucose uptake is not insulin or cold responsive; however, BMAT basal glucose uptake is higher than in white adipose tissue or skeletal muscle, underscoring BMAT’s potential to influence systemic glucose homeostasis.
