Nature Communications (Apr 2019)

Steroid receptor coactivator-1 modulates the function of Pomc neurons and energy homeostasis

  • Yongjie Yang,
  • Agatha A. van der Klaauw,
  • Liangru Zhu,
  • Tessa M. Cacciottolo,
  • Yanlin He,
  • Lukas K. J. Stadler,
  • Chunmei Wang,
  • Pingwen Xu,
  • Kenji Saito,
  • Antentor Hinton,
  • Xiaofeng Yan,
  • Julia M. Keogh,
  • Elana Henning,
  • Matthew C. Banton,
  • Audrey E. Hendricks,
  • Elena G. Bochukova,
  • Vanisha Mistry,
  • Katherine L. Lawler,
  • Lan Liao,
  • Jianming Xu,
  • Stephen O’Rahilly,
  • Qingchun Tong,
  • UK10K Consortium,
  • Inês Barroso,
  • Bert W. O’Malley,
  • I. Sadaf Farooqi,
  • Yong Xu

DOI
https://doi.org/10.1038/s41467-019-08737-6
Journal volume & issue
Vol. 10, no. 1
pp. 1 – 14

Abstract

Read online

Neurons expressing pro-opiomelanocortin (Pomc) regulate food intake and body weight. Here the authors show that Steroid Receptor Coactivator-1 (SRC-1) regulates the function of Pomc expressing neurons, and that rare heterozygous variants found in obese individuals lead to loss of SRC-1 function.