Exon junction complex dependent mRNA localization is linked to centrosome organization during ciliogenesis

Oh Sung Kwon; Rahul Mishra; Adham Safieddine; Emeline Coleno; Quentin Alasseur; Marion Faucourt; Isabelle Barbosa; Edouard Bertrand; Nathalie Spassky; Hervé Le Hir

doi:10.1038/s41467-021-21590-w

Nature Communications (Mar 2021)

Exon junction complex dependent mRNA localization is linked to centrosome organization during ciliogenesis

Oh Sung Kwon,
Rahul Mishra,
Adham Safieddine,
Emeline Coleno,
Quentin Alasseur,
Marion Faucourt,
Isabelle Barbosa,
Edouard Bertrand,
Nathalie Spassky,
Hervé Le Hir

Affiliations

Oh Sung Kwon: Institut de Biologie de l’Ecole Normale Supérieure (IBENS), Ecole Normale Supérieure, CNRS, INSERM, PSL Research University
Rahul Mishra: Institut de Biologie de l’Ecole Normale Supérieure (IBENS), Ecole Normale Supérieure, CNRS, INSERM, PSL Research University
Adham Safieddine: Institut de Génétique Moléculaire de Montpellier, University of Montpellier, CNRS
Emeline Coleno: Institut de Génétique Moléculaire de Montpellier, University of Montpellier, CNRS
Quentin Alasseur: Institut de Biologie de l’Ecole Normale Supérieure (IBENS), Ecole Normale Supérieure, CNRS, INSERM, PSL Research University
Marion Faucourt: Institut de Biologie de l’Ecole Normale Supérieure (IBENS), Ecole Normale Supérieure, CNRS, INSERM, PSL Research University
Isabelle Barbosa: Institut de Biologie de l’Ecole Normale Supérieure (IBENS), Ecole Normale Supérieure, CNRS, INSERM, PSL Research University
Edouard Bertrand: Institut de Génétique Moléculaire de Montpellier, University of Montpellier, CNRS
Nathalie Spassky: Institut de Biologie de l’Ecole Normale Supérieure (IBENS), Ecole Normale Supérieure, CNRS, INSERM, PSL Research University
Hervé Le Hir: Institut de Biologie de l’Ecole Normale Supérieure (IBENS), Ecole Normale Supérieure, CNRS, INSERM, PSL Research University

DOI: https://doi.org/10.1038/s41467-021-21590-w
Journal volume & issue: Vol. 12, no. 1
pp. 1 – 16

Abstract

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Exon junction complexes (EJCs) that mark untranslated mRNA are involved in transport, translation and nonsense-mediated mRNA decay. Here the authors show centrosomal localization of EJCs which appears to be required for both the localization of NIN mRNA around centrosomes and ciliogenesis.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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