Structural basis for membrane attack complex inhibition by CD59

Emma C. Couves; Scott Gardner; Tomas B. Voisin; Jasmine K. Bickel; Phillip J. Stansfeld; Edward W. Tate; Doryen Bubeck

doi:10.1038/s41467-023-36441-z

Nature Communications (Feb 2023)

Structural basis for membrane attack complex inhibition by CD59

Emma C. Couves,
Scott Gardner,
Tomas B. Voisin,
Jasmine K. Bickel,
Phillip J. Stansfeld,
Edward W. Tate,
Doryen Bubeck

Affiliations

Emma C. Couves: Department of Life Sciences, Sir Ernst Chain Building, Imperial College London
Scott Gardner: Department of Life Sciences, Sir Ernst Chain Building, Imperial College London
Tomas B. Voisin: Department of Life Sciences, Sir Ernst Chain Building, Imperial College London
Jasmine K. Bickel: Department of Life Sciences, Sir Ernst Chain Building, Imperial College London
Phillip J. Stansfeld: School of Life Sciences and Department of Chemistry, Gibbet Hill Campus, The University of Warwick
Edward W. Tate: Department of Chemistry, Molecular Sciences Research Hub, Imperial College London
Doryen Bubeck: Department of Life Sciences, Sir Ernst Chain Building, Imperial College London

DOI: https://doi.org/10.1038/s41467-023-36441-z
Journal volume & issue: Vol. 14, no. 1
pp. 1 – 13

Abstract

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CD59 protects human cells from damage by the MAC immune pore. The authors show how CD59 inhibits MAC, by deflecting pore-forming β-hairpins of complement proteins. As well as how the membrane environment influences the role of CD59 in complement regulation and in host-pathogen interactions.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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