Nature Communications (Sep 2020)
Chromatin accessibility mapping of the striatum identifies tyrosine kinase FYN as a therapeutic target for heroin use disorder
- Gabor Egervari,
- Diana Akpoyibo,
- Tanni Rahman,
- John F. Fullard,
- James E. Callens,
- Joseph A. Landry,
- Annie Ly,
- Xianxiao Zhou,
- Noël Warren,
- Mads E. Hauberg,
- Gabriel Hoffman,
- Randy Ellis,
- Jacqueline-Marie N. Ferland,
- Michael L. Miller,
- Eva Keller,
- Bin Zhang,
- Panos Roussos,
- Yasmin L. Hurd
Affiliations
- Gabor Egervari
- Department of Psychiatry, Icahn School of Medicine at Mount Sinai
- Diana Akpoyibo
- Department of Psychiatry, Icahn School of Medicine at Mount Sinai
- Tanni Rahman
- Department of Psychiatry, Icahn School of Medicine at Mount Sinai
- John F. Fullard
- Department of Psychiatry, Icahn School of Medicine at Mount Sinai
- James E. Callens
- Department of Psychiatry, Icahn School of Medicine at Mount Sinai
- Joseph A. Landry
- Department of Psychiatry, Icahn School of Medicine at Mount Sinai
- Annie Ly
- Department of Psychiatry, Icahn School of Medicine at Mount Sinai
- Xianxiao Zhou
- Department of Genetics and Genomic Science, Icahn School of Medicine at Mount Sinai
- Noël Warren
- Department of Psychiatry, Icahn School of Medicine at Mount Sinai
- Mads E. Hauberg
- Department of Psychiatry, Icahn School of Medicine at Mount Sinai
- Gabriel Hoffman
- Department of Genetics and Genomic Science, Icahn School of Medicine at Mount Sinai
- Randy Ellis
- Department of Psychiatry, Icahn School of Medicine at Mount Sinai
- Jacqueline-Marie N. Ferland
- Department of Psychiatry, Icahn School of Medicine at Mount Sinai
- Michael L. Miller
- Department of Psychiatry, Icahn School of Medicine at Mount Sinai
- Eva Keller
- Department of Forensic and Insurance Medicine, Semmelweis University
- Bin Zhang
- Department of Genetics and Genomic Science, Icahn School of Medicine at Mount Sinai
- Panos Roussos
- Department of Psychiatry, Icahn School of Medicine at Mount Sinai
- Yasmin L. Hurd
- Department of Psychiatry, Icahn School of Medicine at Mount Sinai
- DOI
- https://doi.org/10.1038/s41467-020-18114-3
- Journal volume & issue
-
Vol. 11,
no. 1
pp. 1 – 15
Abstract
Epigenetic mechanisms have emerged as contributors to the molecular impairments caused by exposure to environmental factors such as abused substances. Here the authors perform epigenetic profiling of the striatum and identify the tyrosine kinase FYN is an important driver of neurodegenerative-like pathology and drug-taking behaviour.
