Nature Communications (Jan 2023)
Proteogenomics of diffuse gliomas reveal molecular subtypes associated with specific therapeutic targets and immune-evasion mechanisms
- Yunzhi Wang,
- Rongkui Luo,
- Xuan Zhang,
- Hang Xiang,
- Bing Yang,
- Jinwen Feng,
- Mengjie Deng,
- Peng Ran,
- Akesu Sujie,
- Fan Zhang,
- Jiajun Zhu,
- Subei Tan,
- Tao Xie,
- Pin Chen,
- Zixiang Yu,
- Yan Li,
- Dongxian Jiang,
- Xiaobiao Zhang,
- Jian-Yuan Zhao,
- Yingyong Hou,
- Chen Ding
Affiliations
- Yunzhi Wang
- State Key Laboratory of Genetic Engineering and Collaborative Innovation Center for Genetics and Development, School of Life Sciences, Institute of Biomedical Sciences, Human Phenome Institute, Zhongshan Hospital, Fudan University
- Rongkui Luo
- Department of pathology, Zhongshan Hospital, Fudan University
- Xuan Zhang
- Department of Urology, Fudan University Shanghai Cancer Center
- Hang Xiang
- State Key Laboratory of Genetic Engineering and Collaborative Innovation Center for Genetics and Development, School of Life Sciences, Institute of Biomedical Sciences, Human Phenome Institute, Zhongshan Hospital, Fudan University
- Bing Yang
- State Key Laboratory of Genetic Engineering and Collaborative Innovation Center for Genetics and Development, School of Life Sciences, Institute of Biomedical Sciences, Human Phenome Institute, Zhongshan Hospital, Fudan University
- Jinwen Feng
- State Key Laboratory of Genetic Engineering and Collaborative Innovation Center for Genetics and Development, School of Life Sciences, Institute of Biomedical Sciences, Human Phenome Institute, Zhongshan Hospital, Fudan University
- Mengjie Deng
- State Key Laboratory of Genetic Engineering and Collaborative Innovation Center for Genetics and Development, School of Life Sciences, Institute of Biomedical Sciences, Human Phenome Institute, Zhongshan Hospital, Fudan University
- Peng Ran
- State Key Laboratory of Genetic Engineering and Collaborative Innovation Center for Genetics and Development, School of Life Sciences, Institute of Biomedical Sciences, Human Phenome Institute, Zhongshan Hospital, Fudan University
- Akesu Sujie
- Department of pathology, Zhongshan Hospital, Fudan University
- Fan Zhang
- State Key Laboratory of Genetic Engineering and Collaborative Innovation Center for Genetics and Development, School of Life Sciences, Institute of Biomedical Sciences, Human Phenome Institute, Zhongshan Hospital, Fudan University
- Jiajun Zhu
- State Key Laboratory of Genetic Engineering and Collaborative Innovation Center for Genetics and Development, School of Life Sciences, Institute of Biomedical Sciences, Human Phenome Institute, Zhongshan Hospital, Fudan University
- Subei Tan
- State Key Laboratory of Genetic Engineering and Collaborative Innovation Center for Genetics and Development, School of Life Sciences, Institute of Biomedical Sciences, Human Phenome Institute, Zhongshan Hospital, Fudan University
- Tao Xie
- Department of Neurosurgery, Zhongshan Hospital, Fudan University
- Pin Chen
- Department of Neurosurgery, Zhongshan Hospital, Fudan University
- Zixiang Yu
- Department of pathology, Zhongshan Hospital, Fudan University
- Yan Li
- State Key Laboratory of Genetic Engineering and Collaborative Innovation Center for Genetics and Development, School of Life Sciences, Institute of Biomedical Sciences, Human Phenome Institute, Zhongshan Hospital, Fudan University
- Dongxian Jiang
- Department of pathology, Zhongshan Hospital, Fudan University
- Xiaobiao Zhang
- Department of Neurosurgery, Zhongshan Hospital, Fudan University
- Jian-Yuan Zhao
- Institute for Development and Regenerative Cardiovascular Medicine, MOE-Shanghai Key Laboratory of Children’s Environmental Health, Xinhua Hospital, Shanghai Jiao Tong University School of Medicine
- Yingyong Hou
- Department of pathology, Zhongshan Hospital, Fudan University
- Chen Ding
- State Key Laboratory of Genetic Engineering and Collaborative Innovation Center for Genetics and Development, School of Life Sciences, Institute of Biomedical Sciences, Human Phenome Institute, Zhongshan Hospital, Fudan University
- DOI
- https://doi.org/10.1038/s41467-023-36005-1
- Journal volume & issue
-
Vol. 14,
no. 1
pp. 1 – 32
Abstract
The proteogenomic landscape of diffuse gliomas remains to be explored. Here, the authors perform proteogenomic characterisation of diffuse gliomas, investigate the functional role of genomic alterations and suggest three proteomic subgroups.
