Nature Communications (Jul 2019)

Long-term imaging of dorsal root ganglia in awake behaving mice

  • Chao Chen,
  • Jinhui Zhang,
  • Linlin Sun,
  • Yiling Zhang,
  • Wen-Biao Gan,
  • Peifu Tang,
  • Guang Yang

DOI
https://doi.org/10.1038/s41467-019-11158-0
Journal volume & issue
Vol. 10, no. 1
pp. 1 – 11

Abstract

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Imaging sensory neurons in the dorsal root ganglion (DRG) in awake animals is challenging due to motion artefacts and other technical issues. Here the authors develop an intervertebral fusion procedure which minimizes spinal movement thereby enabling chronic imaging of DRG neurons in awake, behaving mice.