Кубанский научный медицинский вестник (Feb 2014)

THE EVOLUTION OF UNDERSTANDING OF THE IMMUNE SYSTEM'S ROLE IN THE PATHOGENESIS OF INFLAMMATORY MYOCARDIAL DISEASES: TH17-MEDIATED IMMUNE MECHANISMS

  • N. R. Paleev,
  • P. N. Paleev,
  • E. I. Ostrovsky,
  • V. I. Karandashov,
  • N. P. Sanina,
  • N. N. Khishova,
  • O. V. Moskalets,
  • A. P. Linnik,
  • A. N. Makarkov

Journal volume & issue
Vol. 0, no. 1
pp. 191 – 195

Abstract

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The review article discusses recent advances in our understanding of viral myocarditis such as pathogenic role of infection and immune mechanisms in acute, sub-acute and chronic phases of the disease. A newly discovered Th17 lymphocyte subset and Interleukin 17 play an important role in the development of inflammatory myocardial diseases. The protective effect of Interferon y and Th1 immune response in acute myocarditis and the role of Th17-mediated mechanisms in progression of acute myocarditis to dilated cardiomyopathy are considered. The evidence of pathogenic role of Th17 lymphocytes in viral myocarditis in human is given.

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