International Journal of General Medicine (Mar 2022)

SIRT7 is a Prognostic Biomarker in Kidney Renal Clear Cell Carcinoma That is Correlated with Immune Cell Infiltration

  • Zhang W,
  • Qian Y,
  • Jin X,
  • Wang Y,
  • Mu L,
  • Jiang Z

Journal volume & issue
Vol. Volume 15
pp. 3167 – 3182

Abstract

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Wei Zhang,1 Yue Qian,1 Xue Jin,2 Yixian Wang,1 Lili Mu,1 Zhixia Jiang2 1Department of Pathogen Biology, Guizhou Nursing Vocational College, Guiyang, People’s Republic of China; 2Guizhou Nursing Vocational College, Guiyang, People’s Republic of ChinaCorrespondence: Wei Zhang, Department of Pathogen Biology, Guizhou Nursing Vocational College, Guiyang, 550000, Guizhou, People’s Republic of China, Email [email protected]: SIRT7 has been shown to be expressed in many cancer types, including clear cell renal cell carcinoma (KIRC), but its functional role in this oncogenic context remains to be firmly defined. This study was designed to explore correlations between SIRT7 and KIRC characteristics using the TCGA database.Methods: Relationships between SIRT7 expression and KIRC patient clinicopathological characteristics were assessed through Kruskal–Wallis tests, Wilcoxon signed-rank tests, and logistic regression analyses. Area under the ROC curve (AUC) values were used to assess the prognostic value of SIRT7 as a means of classifying clear cell renal cell carcinoma patients. The functional role of SIRT7 in this cancer type was assessed through GO/KEGG enrichment analyses and immune cell infiltration analyses.Results: In KIRC patients, higher levels of SIRT7 expression were associated with Race, M stage, T stage (all P < 0.05). SIRT7 offered significant diagnostic value in ROC curve analyses (AUC = 0.912), and elevated SIRT7 levels were linked to worse patient overall survival (OS; P < 0.001). The expression of SIRT7 was independently related with KIRC patient OS (HR: 1.827; 95% CI: 1.346– 2.481; P< 0.001). In GO/KEGG analyses, SIRT7 was found to be associated with ubiquitin-mediated proteolysis and nucleotide excision repair. Higher SIRT7 expression was related to the enhanced infiltration of certain immune cells.Conclusion: Increased SIRT7 expression was associated with a worse KIRC patient prognosis, and immune infiltrates, suggesting it may offer value as a prognostic biomarker for this cancer type.Keywords: SIRT7, biomarker, KIRC, prognosis, tumor-immune infiltration

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