Nature Communications (May 2019)
qDSB-Seq is a general method for genome-wide quantification of DNA double-strand breaks using sequencing
Abstract
Measuring relative frequencies of DNA double-strand breaks between loci does not provide the full physiological relevance of those breaks. Here Rowicka and colleagues present qDSB-Seq method which uses spike-in double-strand breaks induced by a restriction enzyme to accurately quantify DNA damage.