Structural basis for proficient oxidized ribonucleotide insertion in double strand break repair

Joonas A. Jamsen; Akira Sassa; Lalith Perera; David D. Shock; William A. Beard; Samuel H. Wilson

doi:10.1038/s41467-021-24486-x

Nature Communications (Aug 2021)

Structural basis for proficient oxidized ribonucleotide insertion in double strand break repair

Joonas A. Jamsen,
Akira Sassa,
Lalith Perera,
David D. Shock,
William A. Beard,
Samuel H. Wilson

Affiliations

Joonas A. Jamsen: Genome Integrity and Structural Biology Laboratory, National Institute of Environmental Health Sciences, National Institutes of Health, Research Triangle Park
Akira Sassa: Laboratory of Chromatin Metabolism and Epigenetics, Graduate School of Science, Chiba University
Lalith Perera: Genome Integrity and Structural Biology Laboratory, National Institute of Environmental Health Sciences, National Institutes of Health, Research Triangle Park
David D. Shock: Genome Integrity and Structural Biology Laboratory, National Institute of Environmental Health Sciences, National Institutes of Health, Research Triangle Park
William A. Beard: Genome Integrity and Structural Biology Laboratory, National Institute of Environmental Health Sciences, National Institutes of Health, Research Triangle Park
Samuel H. Wilson: Genome Integrity and Structural Biology Laboratory, National Institute of Environmental Health Sciences, National Institutes of Health, Research Triangle Park

DOI: https://doi.org/10.1038/s41467-021-24486-x
Journal volume & issue: Vol. 12, no. 1
pp. 1 – 11

Abstract

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The authors previously showed that pol μ lacks discrimination against oxidized dGTP (8-oxo-dGTP). Here they reveal the structural basis for proficient oxidized ribonucleotide (8-oxo-rGTP) incorporation during double strand break repair by pol μ.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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