Nature Communications (Mar 2019)

Systematic comparison of respiratory syncytial virus-induced memory B cell responses in two anatomical compartments

  • Laila Shehata,
  • Wendy F. Wieland-Alter,
  • Daniel P. Maurer,
  • Eunice Chen,
  • Ruth I. Connor,
  • Peter F. Wright,
  • Laura M. Walker

DOI
https://doi.org/10.1038/s41467-019-09085-1
Journal volume & issue
Vol. 10, no. 1
pp. 1 – 9

Abstract

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Here, the authors isolate over 800 RSV F-specific antibodies from paired nasopharyngeal tonsil and peripheral blood samples from four young children undergoing adenoidectomy and find that adenoid derived antibodies have overall higher binding affinities and neutralization potencies.