ATYPICAL EVOLUTION OF BENIGN CHILDHOOD EPILEPSY WITH CENTRAL TEMPORAL SPIKES AS A MANIFESTATION OF EPILEPTIC ENCEPHALOPATHY

Abstract

Abstract: the article considers options of atypical course and atypical evolution of benign childhood epilepsy with central temporal spikes. Probable mechanism and scheme of development of benign focal epileptiform discharges of childhood on an EEG, their relation to epileptic seizures, as well as mechanism of development of secondary bilateral synchronization and electrical status epilepticus during slow-wave sleep phase is described in the article. The authors suggest a key mechanism in development of atypical evolution through formation of reciprocal self-sustaining epileptic thalamo-cortico-thalamic closed circles, which pathogenesis is based on self-induction and recirculation of epileptiform activity by «re-entry» mechanism. The article presents a clinical example of atypical evolution of rolandic epilepsy into acquired epileptiform opercular syndrome. The authors describe basic principles and approaches to the treatment of syndromes with benign focal epileptiform discharges of childhood and ways of prevention of atypical evolution.

Keywords

• epilepsy
• evolution
• pathogenesis
• children