Frontiers in Oncology (Aug 2020)
Comparison of Gemcitabine Plus Cisplatin vs. Docetaxel Plus Fluorouracil Plus Cisplatin Palliative Chemotherapy for Metastatic Nasopharyngeal Carcinoma
- Xue-Song Sun,
- Xue-Song Sun,
- Xue-Song Sun,
- Xue-Song Sun,
- Xiao-Hao Wang,
- Xiao-Hao Wang,
- Xiao-Hao Wang,
- Xiao-Hao Wang,
- Sai-Lan Liu,
- Sai-Lan Liu,
- Sai-Lan Liu,
- Sai-Lan Liu,
- Dong-Hua Luo,
- Dong-Hua Luo,
- Dong-Hua Luo,
- Dong-Hua Luo,
- Rui Sun,
- Rui Sun,
- Rui Sun,
- Rui Sun,
- Li-Ting Liu,
- Li-Ting Liu,
- Li-Ting Liu,
- Li-Ting Liu,
- Shan-Shan Guo,
- Shan-Shan Guo,
- Shan-Shan Guo,
- Shan-Shan Guo,
- Qiu-Yan Chen,
- Qiu-Yan Chen,
- Qiu-Yan Chen,
- Qiu-Yan Chen,
- Lin-Quan Tang,
- Lin-Quan Tang,
- Lin-Quan Tang,
- Lin-Quan Tang,
- Hai-Qiang Mai,
- Hai-Qiang Mai,
- Hai-Qiang Mai,
- Hai-Qiang Mai
Affiliations
- Xue-Song Sun
- Sun Yat-sen University Cancer Center, Guangzhou, China
- Xue-Song Sun
- State Key Laboratory of Oncology in South China, Guangzhou, China
- Xue-Song Sun
- Collaborative Innovation Center for Cancer Medicine, Guangdong Key Laboratory of Nasopharyngeal Carcinoma Diagnosis and Therapy, Guangzhou, China
- Xue-Song Sun
- Department of Nasopharyngeal Carcinoma, Sun Yat-sen University Cancer Center, Guangzhou, China
- Xiao-Hao Wang
- Sun Yat-sen University Cancer Center, Guangzhou, China
- Xiao-Hao Wang
- State Key Laboratory of Oncology in South China, Guangzhou, China
- Xiao-Hao Wang
- Collaborative Innovation Center for Cancer Medicine, Guangdong Key Laboratory of Nasopharyngeal Carcinoma Diagnosis and Therapy, Guangzhou, China
- Xiao-Hao Wang
- Department of Nasopharyngeal Carcinoma, Sun Yat-sen University Cancer Center, Guangzhou, China
- Sai-Lan Liu
- Sun Yat-sen University Cancer Center, Guangzhou, China
- Sai-Lan Liu
- State Key Laboratory of Oncology in South China, Guangzhou, China
- Sai-Lan Liu
- Collaborative Innovation Center for Cancer Medicine, Guangdong Key Laboratory of Nasopharyngeal Carcinoma Diagnosis and Therapy, Guangzhou, China
- Sai-Lan Liu
- Department of Nasopharyngeal Carcinoma, Sun Yat-sen University Cancer Center, Guangzhou, China
- Dong-Hua Luo
- Sun Yat-sen University Cancer Center, Guangzhou, China
- Dong-Hua Luo
- State Key Laboratory of Oncology in South China, Guangzhou, China
- Dong-Hua Luo
- Collaborative Innovation Center for Cancer Medicine, Guangdong Key Laboratory of Nasopharyngeal Carcinoma Diagnosis and Therapy, Guangzhou, China
- Dong-Hua Luo
- Department of Nasopharyngeal Carcinoma, Sun Yat-sen University Cancer Center, Guangzhou, China
- Rui Sun
- Sun Yat-sen University Cancer Center, Guangzhou, China
- Rui Sun
- State Key Laboratory of Oncology in South China, Guangzhou, China
- Rui Sun
- Collaborative Innovation Center for Cancer Medicine, Guangdong Key Laboratory of Nasopharyngeal Carcinoma Diagnosis and Therapy, Guangzhou, China
- Rui Sun
- Department of Nasopharyngeal Carcinoma, Sun Yat-sen University Cancer Center, Guangzhou, China
- Li-Ting Liu
- Sun Yat-sen University Cancer Center, Guangzhou, China
- Li-Ting Liu
- State Key Laboratory of Oncology in South China, Guangzhou, China
- Li-Ting Liu
- Collaborative Innovation Center for Cancer Medicine, Guangdong Key Laboratory of Nasopharyngeal Carcinoma Diagnosis and Therapy, Guangzhou, China
- Li-Ting Liu
- Department of Nasopharyngeal Carcinoma, Sun Yat-sen University Cancer Center, Guangzhou, China
- Shan-Shan Guo
- Sun Yat-sen University Cancer Center, Guangzhou, China
- Shan-Shan Guo
- State Key Laboratory of Oncology in South China, Guangzhou, China
- Shan-Shan Guo
- Collaborative Innovation Center for Cancer Medicine, Guangdong Key Laboratory of Nasopharyngeal Carcinoma Diagnosis and Therapy, Guangzhou, China
- Shan-Shan Guo
- Department of Nasopharyngeal Carcinoma, Sun Yat-sen University Cancer Center, Guangzhou, China
- Qiu-Yan Chen
- Sun Yat-sen University Cancer Center, Guangzhou, China
- Qiu-Yan Chen
- State Key Laboratory of Oncology in South China, Guangzhou, China
- Qiu-Yan Chen
- Collaborative Innovation Center for Cancer Medicine, Guangdong Key Laboratory of Nasopharyngeal Carcinoma Diagnosis and Therapy, Guangzhou, China
- Qiu-Yan Chen
- Department of Nasopharyngeal Carcinoma, Sun Yat-sen University Cancer Center, Guangzhou, China
- Lin-Quan Tang
- Sun Yat-sen University Cancer Center, Guangzhou, China
- Lin-Quan Tang
- State Key Laboratory of Oncology in South China, Guangzhou, China
- Lin-Quan Tang
- Collaborative Innovation Center for Cancer Medicine, Guangdong Key Laboratory of Nasopharyngeal Carcinoma Diagnosis and Therapy, Guangzhou, China
- Lin-Quan Tang
- Department of Nasopharyngeal Carcinoma, Sun Yat-sen University Cancer Center, Guangzhou, China
- Hai-Qiang Mai
- Sun Yat-sen University Cancer Center, Guangzhou, China
- Hai-Qiang Mai
- State Key Laboratory of Oncology in South China, Guangzhou, China
- Hai-Qiang Mai
- Collaborative Innovation Center for Cancer Medicine, Guangdong Key Laboratory of Nasopharyngeal Carcinoma Diagnosis and Therapy, Guangzhou, China
- Hai-Qiang Mai
- Department of Nasopharyngeal Carcinoma, Sun Yat-sen University Cancer Center, Guangzhou, China
- DOI
- https://doi.org/10.3389/fonc.2020.01295
- Journal volume & issue
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Vol. 10
Abstract
Objective: Our study aimed to compare the efficacy and toxicity of two chemotherapy regimens, gemcitabine plus cisplatin (GP) vs. docetaxel plus, fluorouracil plus cisplatin (TPF), in metastatic nasopharyngeal carcinoma (NPC) patients.Methods: We retrospectively enrolled metastatic NPC patients between July 2006 and December 2016 who were treated with TPF or GP palliative chemotherapy (PCT). The association between the PCT regimens and survival conditions was evaluated by log-rank tests and the Cox proportional hazards model. A cohort was created using propensity score matching with the ratio of 1:1 to clarify the results of the multivariable Cox regression analyses. Overall survival (OS) was the primary endpoint.Results: Of 266 eligible patients, 186 and 80 patients, respectively, received TPF and GP regimen. No significant difference was demonstrated in the survival rate between the GP and TPF groups (3-year OS: 52.6 vs. 50.3%; P = 0.929). However, multivariable analysis suggested receiving GP as an independent protective factor (hazard ratio, 0.864; 95% confidence interval, 0.753–0.992; P = 0.042). In the matched cohort, treatment with GP was also associated with a significantly higher OS (3-year OS: 52.6 vs. 35.6%, P = 0.042). Subgroup analysis indicated that the superiority of GP reflected in patients with secondary metastases rather than primary metastases. The incidence of grade 3 to 4 treatment-related toxicity was more common in the TPF group than in the GP group.Conclusion: Our study suggested that GP might be superior to TPF for metastatic NPC patients, especially those with secondary distant metastases. Further studies are necessary to validate our results.
Keywords