Membrane association and remodeling by intraflagellar transport protein IFT172

Qianmin Wang; Michael Taschner; Kristina A. Ganzinger; Charlotte Kelley; Alethia Villasenor; Michael Heymann; Petra Schwille; Esben Lorentzen; Naoko Mizuno

doi:10.1038/s41467-018-07037-9

Nature Communications (Nov 2018)

Membrane association and remodeling by intraflagellar transport protein IFT172

Qianmin Wang,
Michael Taschner,
Kristina A. Ganzinger,
Charlotte Kelley,
Alethia Villasenor,
Michael Heymann,
Petra Schwille,
Esben Lorentzen,
Naoko Mizuno

Affiliations

Qianmin Wang: Max Planck Institute of Biochemistry, Department of Structural Cell Biology
Michael Taschner: Max Planck Institute of Biochemistry, Department of Structural Cell Biology
Kristina A. Ganzinger: Max Planck Institute of Biochemistry, Department of Cellular and Molecular Biophysics
Charlotte Kelley: Max Planck Institute of Biochemistry, Department of Structural Cell Biology
Alethia Villasenor: Max Planck Institute of Biochemistry, Department of Structural Cell Biology
Michael Heymann: Max Planck Institute of Biochemistry, Department of Cellular and Molecular Biophysics
Petra Schwille: Max Planck Institute of Biochemistry, Department of Cellular and Molecular Biophysics
Esben Lorentzen: Department of Molecular Biology and Genetics, Aarhus University
Naoko Mizuno: Max Planck Institute of Biochemistry, Department of Structural Cell Biology

DOI: https://doi.org/10.1038/s41467-018-07037-9
Journal volume & issue: Vol. 9, no. 1
pp. 1 – 13

Abstract

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Cilia formation requires Intraflagellar transport (IFT) to move ciliary building blocks and signaling components into the cilium. Here authors use in vitro reconstitution and electron microscopy on IFT172 and reveal its ability to remodel large membrane surfaces into small vesicles.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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