Dynamics of the Levels of Cardiospecific Markers in the Blood of Experimental Animals with Modeled Myocardial Necrosis During Different Periods of Readaptation

Abstract

Introduction. Analysis of biomedical aspects of the development of high-altitude pathology includes the concept of "readaptation" that has recently become a matter of scientific interest. Readaptation is the process of reverse adaptation of the structure and function of the human or animal body to the conditions of the external environment, aimed at maintaining the relative constancy of the internal environment of the body — homeostasis. This article is devoted to the study of the course of myocardial necrosis at different periods of readaptation to low mountain conditions after 3 and 30 days of staying in high mountain conditions. Materials and methods. The experimental part of the study was performed using 40 white outbred laboratory male rats aged 3-4 months weighing 200-300 g. The course of catecholamine necrosis of the myocardium in different periods of readaptation was the subject of the study. Blood serum enzymes and the myocardium of laboratory animals represented the objects of the study. Results. It was found that after simulating cardionecrosis on the 3rd, 7th and 30th days of animal readaptation to low mountain conditions, the content of creatine phosphokinase-MB, troponin T, aspartate aminotransferase, the cardiac form of the fatty acid-binding protein in the blood serum was higher than in animals with experimental cardionecrosis in low mountains. Conclusion. Our study indicates a progressive course of cardionecrosis at different points of readaptation, and, therefore, during the period of readaptation, the body functions undergo significant changes that require further careful studying and evaluation.

Keywords

• hypoxia
• highlands
• adaptation
• readaptation
• cardiospecific markers
• cardiomyocytes