Updated scalp heuristics for localizing the dorsolateral prefrontal cortex based on convergent evidence of lesion and brain stimulation studies in depression

Arsalan Mir-Moghtadaei; Shan H. Siddiqi; Kamran Mir-Moghtadaei; Daniel M. Blumberger; Fidel Vila-Rodriguez; Zafiris J. Daskalakis; Michael D. Fox; Jonathan Downar

Brain Stimulation (Mar 2022)

Updated scalp heuristics for localizing the dorsolateral prefrontal cortex based on convergent evidence of lesion and brain stimulation studies in depression

Arsalan Mir-Moghtadaei,
Shan H. Siddiqi,
Kamran Mir-Moghtadaei,
Daniel M. Blumberger,
Fidel Vila-Rodriguez,
Zafiris J. Daskalakis,
Michael D. Fox,
Jonathan Downar

Affiliations

Arsalan Mir-Moghtadaei: Institute of Medical Science, Temerty Faculty of Medicine, University of Toronto, Toronto, ON, Canada; Krembil Research Institute and Centre for Mental Health, University Health Network, Toronto, ON, Canada
Shan H. Siddiqi: Center for Brain Circuit Therapeutics, Brigham and Women's Hospital, Boston, MA, USA; Department of Psychiatry, Harvard Medical School, Boston, MA, USA; Corresponding author. Center for Brain Circuit Therapeutics, 60 Fenwood Rd, Boston, MA, 02115, USA.
Kamran Mir-Moghtadaei: Faculty of Arts and Sciences, University of Toronto, Toronto, Canada
Daniel M. Blumberger: Institute of Medical Science, Temerty Faculty of Medicine, University of Toronto, Toronto, ON, Canada; Department of Psychiatry, Temerty Faculty of Medicine, University of Toronto, Toronto, ON, Canada; Temerty Centre for Therapeutic Brain Intervention and Campbell Family Research Institute, Centre for Addiction and Mental Health, Toronto, ON, Canada
Fidel Vila-Rodriguez: Non-Invasive Neurostimulation Therapies Laboratory, Department of Psychiatry, The University of British Columbia, Vancouver, BC, Canada
Zafiris J. Daskalakis: Department of Psychiatry, School of Medicine, University of California, San Diego Health, CA, USA
Michael D. Fox: Center for Brain Circuit Therapeutics, Brigham and Women's Hospital, Boston, MA, USA; Department of Neurology, Harvard Medical School, Boston, MA, USA
Jonathan Downar: Institute of Medical Science, Temerty Faculty of Medicine, University of Toronto, Toronto, ON, Canada; Krembil Research Institute and Centre for Mental Health, University Health Network, Toronto, ON, Canada; Department of Psychiatry, Temerty Faculty of Medicine, University of Toronto, Toronto, ON, Canada; Corresponding author. Krembil Research Institute, University Health Network, Canada.

Journal volume & issue: Vol. 15, no. 2
pp. 291 – 295

Abstract

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Background: Repetitive transcranial magnetic stimulation (rTMS) is entering wider use as a therapeutic intervention for many psychiatric illnesses. The efficacy of this therapeutic intervention may depend on accurately localizing target brain regions. Recent work investigating whole-brain maps of circuits associated with depression and its successful treatment has identified foci of interest within the dorsolateral prefrontal cortex (DLPFC). Objective: To create an updated scalp heuristic for localizing the DLPFC based on convergent evidence of lesion and brain stimulation studies in depression. Methods: Using the standard MNI ICBM152 anatomical template, we localized the scalp sites at minimum Euclidean distance from target MNI coordinates and performed nasion-inion, tragus-tragus, and head-circumference measurements on the anatomical template. We then derived equations to localize these scalp sites. Results: The derived equations to calculate the arc length X and Y for these new targets are as follows: [Y=((NI+TrTr)/2)×0.3167 ; X=HC×0.1359] for the left anterior DLPFC[ Y=((NI+TrTr)/2)×0.2884; X=HC×0.1352] for the right anterior DLPFC[ Y=((NI+TrTr)/2)×0.2480; X=HC×0.1847] for the left posterior DLPFC[ Y=((NI+TrTr)/2)×0.2316 ; X=HC×0.1968] for the right posterior DLPFC Conclusions: This heuristic may help localize DLPFC targets identified in previous lesion-/stimulation-mapping work. A spreadsheet calculation tool is offered to support use of this heuristic.

Published in Brain Stimulation

ISSN: 1935-861X (Print); 1876-4754 (Online)
Publisher: Elsevier
Country of publisher: United States
LCC subjects: Medicine: Internal medicine: Neurosciences. Biological psychiatry. Neuropsychiatry
Website: https://www.journals.elsevier.com/brain-stimulation

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