Nature Communications (Mar 2019)

Network-based prediction of protein interactions

  • István A. Kovács,
  • Katja Luck,
  • Kerstin Spirohn,
  • Yang Wang,
  • Carl Pollis,
  • Sadie Schlabach,
  • Wenting Bian,
  • Dae-Kyum Kim,
  • Nishka Kishore,
  • Tong Hao,
  • Michael A. Calderwood,
  • Marc Vidal,
  • Albert-László Barabási

DOI
https://doi.org/10.1038/s41467-019-09177-y
Journal volume & issue
Vol. 10, no. 1
pp. 1 – 8

Abstract

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Computational protein-protein interaction (PPI) prediction has the potential to complement experimental efforts to map interactomes. Here, the authors show that proteins tend to interact if one is similar to the other’s partners and that PPI prediction based on this principle is highly accurate.