Nature Communications (Oct 2017)
Simultaneous evolutionary expansion and constraint of genomic heterogeneity in multifocal lung cancer
- Pengfei Ma,
- Yujie Fu,
- Mei-Chun Cai,
- Ying Yan,
- Ying Jing,
- Shengzhe Zhang,
- Minjiang Chen,
- Jie Wu,
- Ying Shen,
- Liang Zhu,
- Hong-Zhuan Chen,
- Wei-Qiang Gao,
- Mengzhao Wang,
- Zhenyu Gu,
- Trever G. Bivona,
- Xiaojing Zhao,
- Guanglei Zhuang
Affiliations
- Pengfei Ma
- State Key Laboratory of Oncogenes and Related Genes, Renji-Med X Clinical Stem Cell Research Center, Ren Ji Hospital, School of Medicine, Shanghai Jiao Tong University
- Yujie Fu
- Department of Thoracic Surgery, Ren Ji Hospital, School of Medicine, Shanghai Jiao Tong University
- Mei-Chun Cai
- State Key Laboratory of Oncogenes and Related Genes, Shanghai Cancer Institute, Ren Ji Hospital, School of Medicine, Shanghai Jiao Tong University
- Ying Yan
- GenenDesign Co., Ltd
- Ying Jing
- State Key Laboratory of Oncogenes and Related Genes, Renji-Med X Clinical Stem Cell Research Center, Ren Ji Hospital, School of Medicine, Shanghai Jiao Tong University
- Shengzhe Zhang
- State Key Laboratory of Oncogenes and Related Genes, Renji-Med X Clinical Stem Cell Research Center, Ren Ji Hospital, School of Medicine, Shanghai Jiao Tong University
- Minjiang Chen
- Department of Respiratory Medicine, Peking Union Medical College Hospital, Peking Union Medical College, Chinese Academy of Medical Sciences
- Jie Wu
- Department of Pathology, The Affiliated Hospital of Qingdao University
- Ying Shen
- Department of Pharmacology and Chemical Biology, Shanghai Jiao Tong University School of Medicine
- Liang Zhu
- Department of Pharmacology and Chemical Biology, Shanghai Jiao Tong University School of Medicine
- Hong-Zhuan Chen
- Department of Pharmacology and Chemical Biology, Shanghai Jiao Tong University School of Medicine
- Wei-Qiang Gao
- State Key Laboratory of Oncogenes and Related Genes, Renji-Med X Clinical Stem Cell Research Center, Ren Ji Hospital, School of Medicine, Shanghai Jiao Tong University
- Mengzhao Wang
- Department of Respiratory Medicine, Peking Union Medical College Hospital, Peking Union Medical College, Chinese Academy of Medical Sciences
- Zhenyu Gu
- GenenDesign Co., Ltd
- Trever G. Bivona
- Department of Medicine, University of California
- Xiaojing Zhao
- Department of Thoracic Surgery, Ren Ji Hospital, School of Medicine, Shanghai Jiao Tong University
- Guanglei Zhuang
- State Key Laboratory of Oncogenes and Related Genes, Renji-Med X Clinical Stem Cell Research Center, Ren Ji Hospital, School of Medicine, Shanghai Jiao Tong University
- DOI
- https://doi.org/10.1038/s41467-017-00963-0
- Journal volume & issue
-
Vol. 8,
no. 1
pp. 1 – 11
Abstract
Across cancer types tumor heterogeneity has been observed, but how this relates to tumor evolution is unclear. Here, the authors sequence multiple synchronous lung cancers, highlighting the evolutionary pressures that simultaneously shape the expansion and constraint of genomic heterogeneity.
