npj Systems Biology and Applications (Apr 2017)

Mechanisms of action of sacubitril/valsartan on cardiac remodeling: a systems biology approach

  • Oriol Iborra-Egea,
  • Carolina Gálvez-Montón,
  • Santiago Roura,
  • Isaac Perea-Gil,
  • Cristina Prat-Vidal,
  • Carolina Soler-Botija,
  • Antoni Bayes-Genis

DOI
https://doi.org/10.1038/s41540-017-0013-4
Journal volume & issue
Vol. 3, no. 1
pp. 1 – 9

Abstract

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Cardiology: Heart Failure Medication Reduces Heart Size The new wonder drug in heart failure management, Sacubitril/Valsartan, rejuvenates the heart by preventing its dilation. Using data from myocardial infarction and heart failure samples, we generated a mathematical model to better understand how Sacubitril/Valsartan modulates pathological heart resize and the combined effect of the drug. Our analysis revealed that Sacubitril/Valsartan mainly acts by blocking both, cell death and the pathological makeover of the outer-membrane of the cardiac cells. These two major processes occur after a heart attack. Most importantly, we discovered a core of 8 proteins that emerge as key players in this process. A better understanding of the mechanism of novel cardiovascular drugs at the most basic level may help decipher future therapies and indications.