The Synthesis of Functionalized Dimethylphosphinoyl Cyclopropanes and Cyclobutanes

Abstract

A simple preparative approach to a series of functionalized dimethylphosphinoyl-containing cyclopropanes and cyclobutanes has been developed; it is based on cyclocondensation of dimethylphosphinoyl acetonitrile with 1,2- and 1,3-dibromoalkanes. Synthetic procedures for obtaining nitriles, amines and carboxylic acids containing in their structure small saturated cyclic rings of cyclopropane or cyclobutane and a dimethylphosphine oxide fragment, which are popular in drug design, have been developed.

Keywords

• dimethylphosphine oxides
• cyclopropane
• cyclobutane
• amines
• carboxylic acids