Nature Communications (Sep 2019)
Alterations in ALK/ROS1/NTRK/MET drive a group of infantile hemispheric gliomas
- Ana S. Guerreiro Stucklin,
- Scott Ryall,
- Kohei Fukuoka,
- Michal Zapotocky,
- Alvaro Lassaletta,
- Christopher Li,
- Taylor Bridge,
- Byungjin Kim,
- Anthony Arnoldo,
- Paul E. Kowalski,
- Yvonne Zhong,
- Monique Johnson,
- Claire Li,
- Arun K. Ramani,
- Robert Siddaway,
- Liana Figueiredo Nobre,
- Pasqualino de Antonellis,
- Christopher Dunham,
- Sylvia Cheng,
- Daniel R. Boué,
- Jonathan L. Finlay,
- Scott L. Coven,
- Inmaculada de Prada,
- Marta Perez-Somarriba,
- Claudia C. Faria,
- Michael A. Grotzer,
- Elisabeth Rushing,
- David Sumerauer,
- Josef Zamecnik,
- Lenka Krskova,
- Miguel Garcia Ariza,
- Ofelia Cruz,
- Andres Morales La Madrid,
- Palma Solano,
- Keita Terashima,
- Yoshiko Nakano,
- Koichi Ichimura,
- Motoo Nagane,
- Hiroaki Sakamoto,
- Maria Joao Gil-da-Costa,
- Roberto Silva,
- Donna L. Johnston,
- Jean Michaud,
- Bev Wilson,
- Frank K. H. van Landeghem,
- Angelica Oviedo,
- P. Daniel McNeely,
- Bruce Crooks,
- Iris Fried,
- Nataliya Zhukova,
- Jordan R. Hansford,
- Amulya Nageswararao,
- Livia Garzia,
- Mary Shago,
- Michael Brudno,
- Meredith S. Irwin,
- Ute Bartels,
- Vijay Ramaswamy,
- Eric Bouffet,
- Michael D. Taylor,
- Uri Tabori,
- Cynthia Hawkins
Affiliations
- Ana S. Guerreiro Stucklin
- Developmental and Stem Cell Biology Program, The Hospital for Sick Children
- Scott Ryall
- Developmental and Stem Cell Biology Program, The Hospital for Sick Children
- Kohei Fukuoka
- The Arthur and Sonia Labatt Brain Tumor Research Centre, The Hospital for Sick Children
- Michal Zapotocky
- The Arthur and Sonia Labatt Brain Tumor Research Centre, The Hospital for Sick Children
- Alvaro Lassaletta
- Department of Hematology and Oncology, The Hospital for Sick Children
- Christopher Li
- Developmental and Stem Cell Biology Program, The Hospital for Sick Children
- Taylor Bridge
- Developmental and Stem Cell Biology Program, The Hospital for Sick Children
- Byungjin Kim
- Developmental and Stem Cell Biology Program, The Hospital for Sick Children
- Anthony Arnoldo
- Department of Pediatric Laboratory Medicine, The Hospital for Sick Children
- Paul E. Kowalski
- Department of Pediatric Laboratory Medicine, The Hospital for Sick Children
- Yvonne Zhong
- Department of Pediatric Laboratory Medicine, The Hospital for Sick Children
- Monique Johnson
- Department of Pediatric Laboratory Medicine, The Hospital for Sick Children
- Claire Li
- Department of Pediatric Laboratory Medicine, The Hospital for Sick Children
- Arun K. Ramani
- Centre for Computational Medicine, The Hospital for Sick Children
- Robert Siddaway
- Developmental and Stem Cell Biology Program, The Hospital for Sick Children
- Liana Figueiredo Nobre
- The Arthur and Sonia Labatt Brain Tumor Research Centre, The Hospital for Sick Children
- Pasqualino de Antonellis
- Developmental and Stem Cell Biology Program, The Hospital for Sick Children
- Christopher Dunham
- Division of Anatomic Pathology, British Columbia Children’s Hospital
- Sylvia Cheng
- Department of Pediatrics, The University of British Columbia
- Daniel R. Boué
- Department of Pathology and Laboratory Medicine, Nationwide Children’s Hospital
- Jonathan L. Finlay
- Division of Hematology/Oncology/Bone Marrow Transplantation, Nationwide Children’s Hospital
- Scott L. Coven
- Division of Hematology/Oncology/Bone Marrow Transplantation, Nationwide Children’s Hospital
- Inmaculada de Prada
- Department of Pathology, Hospital Universitario Niño Jesús
- Marta Perez-Somarriba
- Department of Pediatric Hematology and Oncology, Hospital Universitario Niño Jesús
- Claudia C. Faria
- Division of Neurosurgery, Centro Hospitalar Lisboa Norte, Hospital de Santa Maria
- Michael A. Grotzer
- Department of Oncology and Children’s Research Center, University Children’s Hospital Zurich
- Elisabeth Rushing
- Institute of Neuropathology, University Hospital Zurich
- David Sumerauer
- Second Faculty of Medicine, Charles University and University Hospital Motol
- Josef Zamecnik
- Second Faculty of Medicine, Charles University and University Hospital Motol
- Lenka Krskova
- Second Faculty of Medicine, Charles University and University Hospital Motol
- Miguel Garcia Ariza
- Department of Pediatric Oncology, Hospital Cruces
- Ofelia Cruz
- Department of Pediatric Oncology, Hospital Sant Joan de Déu
- Andres Morales La Madrid
- Department of Pediatric Oncology, Hospital Sant Joan de Déu
- Palma Solano
- Department of Pediatric Oncology, Hospital Infantil Virgen del Rocio
- Keita Terashima
- Children’s Cancer Center, National Center for Child Health and Development
- Yoshiko Nakano
- Division of Brain Tumor Translational Research, National Cancer Center Research Institute
- Koichi Ichimura
- Division of Brain Tumor Translational Research, National Cancer Center Research Institute
- Motoo Nagane
- Department of Neurosurgery, Kyorin University Faculty of Medicine
- Hiroaki Sakamoto
- Department of Pediatric Neurosurgery, Osaka City General Hospital
- Maria Joao Gil-da-Costa
- Division of Pediatric Hematoncology, University Hospital de São João
- Roberto Silva
- Department of Pathology, University Hospital de São João
- Donna L. Johnston
- Division of Hematology/Oncology, Children’s Hospital of Eastern Ontario
- Jean Michaud
- Department of Pathology and Laboratory Medicine, University of Ottawa
- Bev Wilson
- Department of Pediatrics, University of Alberta
- Frank K. H. van Landeghem
- Department of Laboratory Medicine & Pathology, University of Alberta
- Angelica Oviedo
- Department of Anatomic Pathology, Dalhousie University
- P. Daniel McNeely
- Division of Neurosurgery, IWK Health Centre
- Bruce Crooks
- Division of Hematology-Oncology, IWK Health Centre
- Iris Fried
- The Department of Pediatric Hematology Oncology, Hadassah Medical Center
- Nataliya Zhukova
- Children’s Cancer Centre, Royal Children’s Hospital
- Jordan R. Hansford
- Children’s Cancer Centre, Royal Children’s Hospital
- Amulya Nageswararao
- Division of Pediatric Hematology/Oncology, Mayo Clinic
- Livia Garzia
- Department of Medicine, McGill University
- Mary Shago
- Department of Laboratory Medicine and Pathobiology, University of Toronto
- Michael Brudno
- Centre for Computational Medicine, The Hospital for Sick Children
- Meredith S. Irwin
- Department of Hematology and Oncology, The Hospital for Sick Children
- Ute Bartels
- Department of Hematology and Oncology, The Hospital for Sick Children
- Vijay Ramaswamy
- The Arthur and Sonia Labatt Brain Tumor Research Centre, The Hospital for Sick Children
- Eric Bouffet
- Department of Hematology and Oncology, The Hospital for Sick Children
- Michael D. Taylor
- Developmental and Stem Cell Biology Program, The Hospital for Sick Children
- Uri Tabori
- Developmental and Stem Cell Biology Program, The Hospital for Sick Children
- Cynthia Hawkins
- Developmental and Stem Cell Biology Program, The Hospital for Sick Children
- DOI
- https://doi.org/10.1038/s41467-019-12187-5
- Journal volume & issue
-
Vol. 10,
no. 1
pp. 1 – 13
Abstract
Infant gliomas behave differently to their childhood or adult counterparts. Here, the authors perform a large-scale genetic analysis of these tumours, revealing genetic alterations which may offer therapeutic opportunities.
