Majallah-i Dānishgāh-i ̒Ulūm-i Pizishkī-i Bābul (Mar 2023)
Association of BMI and Age with Gleason Score and PSA in Patients with Prostate Cancer
Abstract
Background and Objective: Obesity has produced conflicting results on various indices of prostate cancer diagnosis. Since the effect of body mass index (BMI) on Gleason score and prostate specific antigen (PSA) as well as the overall classified risk of prostate cancer results is important, the present study was conducted to investigate the association of BMI and age with Gleason score and PSA in Patients with prostate cancer. Methods: In this cross-sectional study, 310 prostate cancer patients referred to the affiliated hospitals of Babol University of Medical Sciences from 2011 to 2021 were evaluated in terms of age, height, weight, PSA and Gleason score. Based on BMI, the patients were divided into three groups: obese (BMI≥30), overweight (BMI=25-30) and normal weight (BMI7) and were divided into three categories based on PSA: 4-10, 10-20 and more than 20. Then, the association of BMI and age with Gleason score and PSA was investigated. Findings: The mean BMI of the patients was 26.3±3.77 kg/m2. The mean PSA was 35.72±8.5 ng/dL and the mean Gleason score was 7.1±1.11. The mean Gleason score increased with increasing age (p<0.001, r=0.307). A higher Gleason score had a significant relationship with PSA increase (p<0.001, r=0.485). BMI had no significant association with Gleason score (r=0.072, p=0.102). PSA decreased slightly with increasing BMI (p=0.006, r=0.157). Conclusion: The results of the study showed that increasing age is associated with a higher Gleason score. But the increase in BMI is not related to increased risk of prostate cancer and increased Gleason score.
