Microbiota-based markers predictive of development of Clostridioides difficile infection

Matilda Berkell; Mohamed Mysara; Basil Britto Xavier; Cornelis H. van Werkhoven; Pieter Monsieurs; Christine Lammens; Annie Ducher; Maria J. G. T. Vehreschild; Herman Goossens; Jean de Gunzburg; Marc J. M. Bonten; Surbhi Malhotra-Kumar; the ANTICIPATE study group

doi:10.1038/s41467-021-22302-0

Nature Communications (Apr 2021)

Microbiota-based markers predictive of development of Clostridioides difficile infection

Matilda Berkell,
Mohamed Mysara,
Basil Britto Xavier,
Cornelis H. van Werkhoven,
Pieter Monsieurs,
Christine Lammens,
Annie Ducher,
Maria J. G. T. Vehreschild,
Herman Goossens,
Jean de Gunzburg,
Marc J. M. Bonten,
Surbhi Malhotra-Kumar,
the ANTICIPATE study group

Affiliations

Matilda Berkell: Laboratory of Medical Microbiology, Vaccine & Infectious Disease Institute, University of Antwerp
Mohamed Mysara: Laboratory of Medical Microbiology, Vaccine & Infectious Disease Institute, University of Antwerp
Basil Britto Xavier: Laboratory of Medical Microbiology, Vaccine & Infectious Disease Institute, University of Antwerp
Cornelis H. van Werkhoven: Julius Center for Health Sciences and Primary Care, University Medical Center Utrecht, Utrecht University
Pieter Monsieurs: Microbiology Unit, Interdisciplinary Biosciences, Belgian Nuclear Research Centre, SCK–CEN
Christine Lammens: Laboratory of Medical Microbiology, Vaccine & Infectious Disease Institute, University of Antwerp
Annie Ducher: Da Volterra
Maria J. G. T. Vehreschild: Department of Internal Medicine, Center for Integrated Oncology Aachen Bonn Cologne Duesseldorf, University of Cologne
Herman Goossens: Laboratory of Medical Microbiology, Vaccine & Infectious Disease Institute, University of Antwerp
Jean de Gunzburg: Da Volterra
Marc J. M. Bonten: Julius Center for Health Sciences and Primary Care, University Medical Center Utrecht, Utrecht University
Surbhi Malhotra-Kumar: Laboratory of Medical Microbiology, Vaccine & Infectious Disease Institute, University of Antwerp
the ANTICIPATE study group

DOI: https://doi.org/10.1038/s41467-021-22302-0
Journal volume & issue: Vol. 12, no. 1
pp. 1 – 14

Abstract

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Clostridioides difficile infection (CDI) is the most common cause of antibiotic-associated diarrhoea (AAD); however, markers predictive of CDI or AAD development are as yet lacking. Here, to identify markers predictive of CDI, the authors profile the intestinal microbiota of 945 hospitalised patients from 34 hospitals in 6 different European countries and show distinct microbiota enriched in Enterococcus and depleted of Ruminococcus, Blautia, Prevotella and Bifidobacterium compared to non-CDI patients.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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