Biomimetic enantioselective synthesis of β,β-difluoro-α-amino acid derivatives

Abstract

Organocatalysed 1,3-proton shifts can offer efficient access to chiral nonracemic fluorinated products. Here chiral amino amides are obtained in high enantiomeric ratio via enantioselective 1,3- proton shift of β,β-difluoro-αimino amides.