Nature Communications (Oct 2016)

The Nedd4-2/Ndfip1 axis is a negative regulator of IgE-mediated mast cell activation

  • Kwok Ho Yip,
  • Natasha Kolesnikoff,
  • Nicholas Hauschild,
  • Lisa Biggs,
  • Angel F. Lopez,
  • Stephen J. Galli,
  • Sharad Kumar,
  • Michele A. Grimbaldeston

DOI
https://doi.org/10.1038/ncomms13198
Journal volume & issue
Vol. 7, no. 1
pp. 1 – 14

Abstract

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Aberrant activation of the IgE receptor on mast cells leads to allergic responses. Here, the authors identify an E3 ligase and adaptor protein that can reduce IgE signalling by targeting phosphorylated-Syk for degradation.