Establishment of an induced pluripotent stem cell line (FDEENTi001-A) from a patient with pathological myopia

Xinyue Bai; Xianjie Yang; Yun Cheng; Ling Chen

Stem Cell Research (Jan 2019)

Establishment of an induced pluripotent stem cell line (FDEENTi001-A) from a patient with pathological myopia

Xinyue Bai,
Xianjie Yang,
Yun Cheng,
Ling Chen

Affiliations

Xinyue Bai: Department of Ophthalmology & Vision Science, Eye & ENT Hospital, Shanghai Medical School, Fudan University, Shanghai, China; Key NHC Key Laboratory of Myopia (Fudan University), Laboratory of Myopia, Chinese Academy of Medical Sciences, China
Xianjie Yang: Jules Stein Eye Institute, University of California Los Angeles, California, USA
Yun Cheng: Department of Ophthalmology & Vision Science, Eye & ENT Hospital, Shanghai Medical School, Fudan University, Shanghai, China; Key NHC Key Laboratory of Myopia (Fudan University), Laboratory of Myopia, Chinese Academy of Medical Sciences, China
Ling Chen: Department of Ophthalmology & Vision Science, Eye & ENT Hospital, Shanghai Medical School, Fudan University, Shanghai, China; Key NHC Key Laboratory of Myopia (Fudan University), Laboratory of Myopia, Chinese Academy of Medical Sciences, China; Corresponding author at: Department of Ophthalmology & Vision Science, Eye & ENT Hospital, Fudan University, Shanghai, China.

Journal volume & issue: Vol. 34

Abstract

Read online

Pathological myopia (PM) is a retinal degenerative disease with an increasing prevalence in Asia. The peripheral blood mononuclear cells (PBMCs) from a patient with PM were successfully reprogrammed to induced pluripotent stem cells (iPSCs) using integration-free method, Sendai viral (SeV) vectors expressing OCT4, SOX2, KLF4 and C-MYC. This line may provide a useful resource for exploring the pathogenesis of PM.

Published in Stem Cell Research

ISSN: 1873-5061 (Print); 1876-7753 (Online)
Publisher: Elsevier
Country of publisher: Netherlands
LCC subjects: Science: Biology (General)
Website: https://www.journals.elsevier.com/stem-cell-research

About the journal