Nanomechanical DNA resonators for sensing and structural analysis of DNA-ligand complexes

Stefano Stassi; Monica Marini; Marco Allione; Sergei Lopatin; Domenico Marson; Erik Laurini; Sabrina Pricl; Candido Fabrizio Pirri; Carlo Ricciardi; Enzo Di Fabrizio

doi:10.1038/s41467-019-09612-0

Nature Communications (Apr 2019)

Nanomechanical DNA resonators for sensing and structural analysis of DNA-ligand complexes

Stefano Stassi,
Monica Marini,
Marco Allione,
Sergei Lopatin,
Domenico Marson,
Erik Laurini,
Sabrina Pricl,
Candido Fabrizio Pirri,
Carlo Ricciardi,
Enzo Di Fabrizio

Affiliations

Stefano Stassi: Dipartimento di Scienza Applicata e Tecnologia, Politecnico di Torino, Corso Duca Degli Abruzzi, 24
Monica Marini: Dipartimento di Scienza Applicata e Tecnologia, Politecnico di Torino, Corso Duca Degli Abruzzi, 24
Marco Allione: Physical Science and Engineering and BESE Divisions, King Abdullah University of Science and Technology
Sergei Lopatin: Imaging and Characterization Core Lab, King Abdullah University of Science and Technology
Domenico Marson: Molecular Biology and Nanotechnology Laboratory (MolBNL@UniTS) – DEA, University of Trieste
Erik Laurini: Molecular Biology and Nanotechnology Laboratory (MolBNL@UniTS) – DEA, University of Trieste
Sabrina Pricl: Molecular Biology and Nanotechnology Laboratory (MolBNL@UniTS) – DEA, University of Trieste
Candido Fabrizio Pirri: Dipartimento di Scienza Applicata e Tecnologia, Politecnico di Torino, Corso Duca Degli Abruzzi, 24
Carlo Ricciardi: Dipartimento di Scienza Applicata e Tecnologia, Politecnico di Torino, Corso Duca Degli Abruzzi, 24
Enzo Di Fabrizio: Physical Science and Engineering and BESE Divisions, King Abdullah University of Science and Technology

DOI: https://doi.org/10.1038/s41467-019-09612-0
Journal volume & issue: Vol. 10, no. 1
pp. 1 – 10

Abstract

Read online

Intercalating molecules can significantly change the conformation of DNA. Here, the authors fabricated resonators fully composed of DNA forming bundles between microfabricated pillars to study the vibration property of the DNA bundles with/without intercalant molecules.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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