Efficacy of Co-trimoxazol and Rifampine in treatment of childhood Brucellosis

Abstract

Objective: Brucellosis is a common infectious disease in our country and it is frequently seen in children. Since different therapeutic methods for childhood Brucellosis are suggested, this study was performed to evaluate the efficacy of Co-trimoxazol and Rifampine in the treatment of children with Brucellosis. Methods: This study was conducted on 96 cases of childhood Brucellosis without any control group in Babol during 1995 to 1998. After diagnosis of Brucellosis all patients were treated by Co-trimoxazol and Rifampine for six weeks, and then all patients were followed for 12 months. Findings: From a total of 96 cases, 53 (55%) were male and 43 (45%) were female. Mean age was 10.3±3.4 years. The mean interval between presentation of the disease and the final diagnosis was 27±17 days. 82 cases completed the treatment and followed up for 12 months, and 2 cases (2.4%) had relapses. Conclusion: Combination therapy with Co-trimoxazol and Rifampine for six weeks is a good regimen with a low relapse rate, however further controlled trials must confirm these results.

Keywords

• brucellosis
• children
• treatment
• relapse
• co-trimoxazol
• rifampine