Recent Development of Nanomaterials for Transdermal Drug Delivery
Moong Yan Leong,
Yeo Lee Kong,
Kevin Burgess,
Won Fen Wong,
Gautam Sethi,
Chung Yeng Looi
Affiliations
Moong Yan Leong
School of Biosciences, Faculty of Health and Medical Sciences, Taylor’s University Lakeside Campus, Subang Jaya, Selangor Darul Ehsan 47500, Malaysia
Yeo Lee Kong
Department of Engineering and Applied Science, America Degree Program, Taylor’s University Lakeside Campus, Subang Jaya, Selangor Darul Ehsan 47500, Malaysia
Kevin Burgess
Department of Chemistry, Texas A&M University, P.O. Box 30012, College Station, TX 77842, USA
Won Fen Wong
Department of Medical Microbiology, Faculty of Medicine, Universiti Malaya, Kuala Lumpur 50603, Malaysia
Gautam Sethi
Department of Pharmacology, Yong Loo Lin School of Medicine, National University of Singapore, Singapore 117600, Singapore
Chung Yeng Looi
School of Biosciences, Faculty of Health and Medical Sciences, Taylor’s University Lakeside Campus, Subang Jaya, Selangor Darul Ehsan 47500, Malaysia
Nano-engineered medical products first appeared in the last decade. The current research in this area focuses on developing safe drugs with minimal adverse effects associated with the pharmacologically active cargo. Transdermal drug delivery, an alternative to oral administration, offers patient convenience, avoids first-pass hepatic metabolism, provides local targeting, and reduces effective drug toxicities. Nanomaterials provide alternatives to conventional transdermal drug delivery including patches, gels, sprays, and lotions, but it is crucial to understand the transport mechanisms involved. This article reviews the recent research trends in transdermal drug delivery and emphasizes the mechanisms and nano-formulations currently in vogue.
