Acid Suppression Use Among Infants in One Tertiary Children's Hospital in China, 2015–2018: A Retrospective Observational Study

Yue Zhou; Lina Xu; Haishaerjiang Wushouer; Haishaerjiang Wushouer; Aichen Yu; Ziyue Xu; Chaoyang Chen; Chaoyang Chen; Yimin Cui; Yimin Cui; Yimin Cui; Qinghong Lu; Xiaodong Guan; Xiaodong Guan; Luwen Shi; Luwen Shi

doi:10.3389/fped.2021.679203

Frontiers in Pediatrics (May 2021)

Acid Suppression Use Among Infants in One Tertiary Children's Hospital in China, 2015–2018: A Retrospective Observational Study

Yue Zhou,
Lina Xu,
Haishaerjiang Wushouer,
Haishaerjiang Wushouer,
Aichen Yu,
Ziyue Xu,
Chaoyang Chen,
Chaoyang Chen,
Yimin Cui,
Yimin Cui,
Yimin Cui,
Qinghong Lu,
Xiaodong Guan,
Xiaodong Guan,
Luwen Shi,
Luwen Shi

Affiliations

Yue Zhou: Department of Pharmacy Administration and Clinical Pharmacy, School of Pharmaceutical Sciences, Peking University, Beijing, China
Lina Xu: Department of Pharmacy, Jiangxi Provincial Children's Hospital, Nanchang, China
Haishaerjiang Wushouer: Department of Pharmacy Administration and Clinical Pharmacy, School of Pharmaceutical Sciences, Peking University, Beijing, China
Haishaerjiang Wushouer: International Research Center for Medicinal Administration (IRCMA), Peking University, Beijing, China
Aichen Yu: Department of Pharmacy Administration and Clinical Pharmacy, School of Pharmaceutical Sciences, Peking University, Beijing, China
Ziyue Xu: Department of Pharmacy Administration and Clinical Pharmacy, School of Pharmaceutical Sciences, Peking University, Beijing, China
Chaoyang Chen: Department of Pharmacy Administration and Clinical Pharmacy, School of Pharmaceutical Sciences, Peking University, Beijing, China
Chaoyang Chen: Department of Pharmacy, Peking University First Hospital, Beijing, China
Yimin Cui: Department of Pharmacy Administration and Clinical Pharmacy, School of Pharmaceutical Sciences, Peking University, Beijing, China
Yimin Cui: Department of Pharmacy, Peking University First Hospital, Beijing, China
Yimin Cui: Institute of Clinical Pharmacology, Peking University, Beijing, China
Qinghong Lu: Department of Pharmacy, Jiangxi Provincial Children's Hospital, Nanchang, China
Xiaodong Guan: Department of Pharmacy Administration and Clinical Pharmacy, School of Pharmaceutical Sciences, Peking University, Beijing, China
Xiaodong Guan: International Research Center for Medicinal Administration (IRCMA), Peking University, Beijing, China
Luwen Shi: Department of Pharmacy Administration and Clinical Pharmacy, School of Pharmaceutical Sciences, Peking University, Beijing, China
Luwen Shi: International Research Center for Medicinal Administration (IRCMA), Peking University, Beijing, China

DOI: https://doi.org/10.3389/fped.2021.679203
Journal volume & issue: Vol. 9

Abstract

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Clinical guidelines emphasized that physicians should be cautious when prescribing acid suppressions to infants. Histamine-2 receptor antagonists (H2RAs) and proton pump inhibitors (PPIs) are not approved for use in infants aged below 2 years in China. We investigated H2RA/PPI use in infants aged below 2 years hospitalized between 1st January 2015 and 31st December 2018 in a Chinese tertiary children's hospital. Our study observed that H2RAs/PPIs were frequently prescribed with a prevalence of 4.4% (7,158/162,192). The frequency of PPI use was over two-fold than that of H2RA use (71.9%, 5,148/7,158; 28.1%, 2,011/7,158). H2RAs/PPIs were commonly used to treat infants without digestive system diseases (57.5%, 4,118/7,158). Further studies are urgently needed to evaluate the effectiveness and safety of H2RAs/PPIs in infants.

Published in Frontiers in Pediatrics

ISSN: 2296-2360 (Online)
Publisher: Frontiers Media S.A.
Country of publisher: Switzerland
LCC subjects: Medicine: Pediatrics
Website: http://journal.frontiersin.org/journal/pediatrics

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