The autophagy receptor p62/SQST-1 promotes proteostasis and longevity in C. elegans by inducing autophagy

Caroline Kumsta; Jessica T. Chang; Reina Lee; Ee Phie Tan; Yongzhi Yang; Rute Loureiro; Elizabeth H. Choy; Shaun H. Y. Lim; Isabel Saez; Alexander Springhorn; Thorsten Hoppe; David Vilchez; Malene Hansen

doi:10.1038/s41467-019-13540-4

Nature Communications (Dec 2019)

The autophagy receptor p62/SQST-1 promotes proteostasis and longevity in C. elegans by inducing autophagy

Caroline Kumsta,
Jessica T. Chang,
Reina Lee,
Ee Phie Tan,
Yongzhi Yang,
Rute Loureiro,
Elizabeth H. Choy,
Shaun H. Y. Lim,
Isabel Saez,
Alexander Springhorn,
Thorsten Hoppe,
David Vilchez,
Malene Hansen

Affiliations

Caroline Kumsta: Sanford Burnham Prebys Medical Discovery Institute, Development, Aging and Regeneration Program
Jessica T. Chang: Sanford Burnham Prebys Medical Discovery Institute, Development, Aging and Regeneration Program
Reina Lee: Sanford Burnham Prebys Medical Discovery Institute, Development, Aging and Regeneration Program
Ee Phie Tan: Sanford Burnham Prebys Medical Discovery Institute, Development, Aging and Regeneration Program
Yongzhi Yang: Sanford Burnham Prebys Medical Discovery Institute, Development, Aging and Regeneration Program
Rute Loureiro: Institute for Genetics and Cologne Excellence Cluster for Cellular Stress Responses in Aging-Associated Diseases (CECAD), University of Cologne
Elizabeth H. Choy: Sanford Burnham Prebys Medical Discovery Institute, Development, Aging and Regeneration Program
Shaun H. Y. Lim: Sanford Burnham Prebys Medical Discovery Institute, Development, Aging and Regeneration Program
Isabel Saez: Institute for Genetics and Cologne Excellence Cluster for Cellular Stress Responses in Aging-Associated Diseases (CECAD), University of Cologne
Alexander Springhorn: Institute for Genetics and Cologne Excellence Cluster for Cellular Stress Responses in Aging-Associated Diseases (CECAD), University of Cologne
Thorsten Hoppe: Institute for Genetics and Cologne Excellence Cluster for Cellular Stress Responses in Aging-Associated Diseases (CECAD), University of Cologne
David Vilchez: Institute for Genetics and Cologne Excellence Cluster for Cellular Stress Responses in Aging-Associated Diseases (CECAD), University of Cologne
Malene Hansen: Sanford Burnham Prebys Medical Discovery Institute, Development, Aging and Regeneration Program

DOI: https://doi.org/10.1038/s41467-019-13540-4
Journal volume & issue: Vol. 10, no. 1
pp. 1 – 12

Abstract

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While the cellular recycling process autophagy has been linked to aging, the impact of selective autophagy on lifespan remains unclear. Here Kumsta et al. show that the autophagy receptor p62/SQSTM1 is required for hormetic benefits and p62/SQSTM1 overexpression is sufficient to extend C. elegans lifespan and improve proteostasis.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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