Canadian Journal of Gastroenterology (Jan 1997)

Clinical, Pathological and Molecular Genetic Findings in Small Intestinal Follicle Centre Cell Lymphoma

  • Hugh J Freeman,
  • Michelle E Anderson,
  • Randy D Gascoyne

DOI
https://doi.org/10.1155/1997/507318
Journal volume & issue
Vol. 11, no. 1
pp. 31 – 34

Abstract

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A 44-year-old male was evaluated for an iron deficiency anemia. Endoscopic investigation revealed marked serpiginous ulceration of the proximal small intestine due to a B cell lymphoma. Endoscopic small intestinal mucosal biopsies revealed a nodular lymphoid infiltrate, and polymerase chain reaction of biopsy material from the same site demonstrated rearrangement of the bcl-2 gene, the molecular equivalent of the t(14;18) chromosomal translocation. Primary small bowel follicular small cleaved cell lymphoma was diagnosed. Endoscopic tissue biopsies for immunophenotyping, molecular genetic studies or both are a valuable diagnostic aid for precise classification of lymphoid neoplasms in the gastrointestinal tract.