Hybrid structures composed of layered one-dimensional (1D) and two-dimensional (2D) materials opened new perspectives and opportunities through the build-up of hetero-junctions with versatile layered structures and led to fascinating fundamental phenomena and advanced devices. We succeeded in depositing by magnetron sputtering vertically aligned 1D ZnO nanorods on 2D MoS2 flakes obtained by exfoliation, preserving the structure of the 2D materials. The photoluminescence (PL) optical properties of the hybrid structure were assessed towards developing a contactless optical chemical sensor.