Bathyptilones: Terpenoids from an Antarctic Sea Pen, <i>Anthoptilum grandiflorum</i> (Verrill, 1879)

Santana  A.L. Thomas; Anthony Sanchez; Younghoon Kee; Nerida  G. Wilson; Bill  J. Baker

doi:10.3390/md17090513

Marine Drugs (Sep 2019)

Bathyptilones: Terpenoids from an Antarctic Sea Pen, <i>Anthoptilum grandiflorum</i> (Verrill, 1879)

Santana A.L. Thomas,
Anthony Sanchez,
Younghoon Kee,
Nerida G. Wilson,
Bill J. Baker

Affiliations

Santana A.L. Thomas: Department of Chemistry, University of South Florida, Tampa, FL 33620, USA
Anthony Sanchez: Department of Cellular, Microbiology and Molecular Biology, University of South Florida, Tampa, FL 33620, USA
Younghoon Kee: Department of Cellular, Microbiology and Molecular Biology, University of South Florida, Tampa, FL 33620, USA
Nerida G. Wilson: Western Australia Museum and the University of Western Australia, Perth, WA 6106, Australia
Bill J. Baker: Department of Chemistry, University of South Florida, Tampa, FL 33620, USA

DOI: https://doi.org/10.3390/md17090513
Journal volume & issue: Vol. 17, no. 9
p. 513

Abstract

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An Antarctic coral belonging to the order Pennatulacea, collected during the 2013 austral autumn by trawl from 662 to 944 m depth, has yielded three new briarane diterpenes, bathyptilone A-C (1−3) along with a trinorditerpene, enbepeanone A (4), which bears a new carbon skeleton. Structure elucidation was facilitated by one- and two-dimensional NMR spectroscopy, mass spectrometry and confirmed by X-ray crystallography. The three compounds were screened in four cancer cell lines. Bathyptilone A displayed selective nanomolar cytotoxicity against the neurogenic mammalian cell line Ntera-2.

Published in Marine Drugs

ISSN: 1660-3397 (Online)
Publisher: MDPI AG
Country of publisher: Switzerland
LCC subjects: Science: Biology (General)
Website: http://www.mdpi.com/journal/marinedrugs

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