Clinicopathological Characteristics and Prognosis of Breast Cancer in Young Women – A Single Center Study in a Developing Country

Abstract

Xiaoliang Sun, Jun Liu, Haoyang Ji, Meng Yang, Yao Lu Department of General Surgery, China-Japan Friendship Hospital, Beijing, People’s Republic of ChinaCorrespondence: Yao LuDepartment of General Surgery, China-Japan Friendship Hospital, No. 2 Yinghua East Road, Chaoyang District, Beijing, 100029, People’s Republic of ChinaEmail [email protected]: Breast cancer (BC) in young women tends to be more aggressive. This study highlights the clinicopathological features and outcomes of young breast cancer (YBC) patients in a developing country.Methods: Consecutive patients aged 35 years or younger with a pathologically confirmed diagnosis of breast cancer treated and followed up at our department were included. Medical records and follow-up databases were reviewed and documented.Results: The rate of breast conservation and reconstruction surgery is higher in YBC patients. YBC patients are more likely to have tumors over 5cm, high-grade, hormone receptor negative, triple negative and stage III than old patients. There was no statistically significant difference in the pathological type, lymph node metastasis, and HER2 status. The median follow-up time was 96 months. The disease-free survival (DFS) was significantly worse in the YBC group. However, the overall survival (OS) had no difference between the two groups.Conclusion: YBC patients had more aggressive pathological features, such as hormone receptor negative, triple negative, high-grade and advanced stage, and poorer DFS than the old counterparts.Keywords: young age, breast cancer, clinicopathological characteristics, survival, molecular subtypes

Keywords

• young age
• breast cancer
• clinicopathological characteristics
• survival
• molecular subtypes