A fast Myosin super enhancer dictates muscle fiber phenotype through competitive interactions with Myosin genes

Matthieu Dos Santos; Stéphanie Backer; Frédéric Auradé; Matthew Man-Kin Wong; Maud Wurmser; Rémi Pierre; Francina Langa; Marcio Do Cruzeiro; Alain Schmitt; Jean-Paul Concordet; Athanassia Sotiropoulos; F. Jeffrey Dilworth; Daan Noordermeer; Frédéric Relaix; Iori Sakakibara; Pascal Maire

doi:10.1038/s41467-022-28666-1

Nature Communications (Feb 2022)

A fast Myosin super enhancer dictates muscle fiber phenotype through competitive interactions with Myosin genes

Matthieu Dos Santos,
Stéphanie Backer,
Frédéric Auradé,
Matthew Man-Kin Wong,
Maud Wurmser,
Rémi Pierre,
Francina Langa,
Marcio Do Cruzeiro,
Alain Schmitt,
Jean-Paul Concordet,
Athanassia Sotiropoulos,
F. Jeffrey Dilworth,
Daan Noordermeer,
Frédéric Relaix,
Iori Sakakibara,
Pascal Maire

Affiliations

Matthieu Dos Santos: Université de Paris, Institut Cochin, INSERM, CNRS
Stéphanie Backer: Université de Paris, Institut Cochin, INSERM, CNRS
Frédéric Auradé: Univ Paris Est Creteil, INSERM, EnvA, EFS, AP-HP, IMRB
Matthew Man-Kin Wong: Regenerative Medicine Program. Ottawa Hospital Research Institute
Maud Wurmser: Université de Paris, Institut Cochin, INSERM, CNRS
Rémi Pierre: Université de Paris, Institut Cochin, INSERM, CNRS
Francina Langa: Institut Pasteur
Marcio Do Cruzeiro: Université de Paris, Institut Cochin, INSERM, CNRS
Alain Schmitt: Université de Paris, Institut Cochin, INSERM, CNRS
Jean-Paul Concordet: MNHN
Athanassia Sotiropoulos: Université de Paris, Institut Cochin, INSERM, CNRS
F. Jeffrey Dilworth: Regenerative Medicine Program. Ottawa Hospital Research Institute
Daan Noordermeer: Université Paris-Saclay, CEA, CNRS, Institute for Integrative Biology of the Cell (I2BC)
Frédéric Relaix: Univ Paris Est Creteil, INSERM, EnvA, EFS, AP-HP, IMRB
Iori Sakakibara: Université de Paris, Institut Cochin, INSERM, CNRS
Pascal Maire: Université de Paris, Institut Cochin, INSERM, CNRS

DOI: https://doi.org/10.1038/s41467-022-28666-1
Journal volume & issue: Vol. 13, no. 1
pp. 1 – 17

Abstract

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The contractile properties of adult myofibers are shaped by their Myosin heavy chain isoform content. Here the authors show that a super enhancer controls the spatiotemporal expression of the genes at the fast myosin heavy chain locus by DNA looping and that this expression profile is recapitulated in a rainbow transgenic mouse model of the locus.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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