Reviews in Cardiovascular Medicine (Feb 2024)

Chest Pain: Wellens Syndrome Due to Spontaneous Dissection of the Left Anterior Descending Coronary Artery — A Case Report and Literature Review

  • Giuseppe Clemente,
  • Cosimo Quaranta,
  • Maria Grazia Basso,
  • Chiara Pintus,
  • Giuliana Rizzo,
  • Celeste Vullo,
  • Silvia Bruno,
  • Francesca Castro,
  • Danilo Puccio,
  • Roberto Nola,
  • Giuseppina Novo,
  • Egle Corrado,
  • Antonino Tuttolomondo

DOI
https://doi.org/10.31083/j.rcm2502070
Journal volume & issue
Vol. 25, no. 2
p. 70

Abstract

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Wellens syndrome is an abnormal electrocardiographic pattern characterized by biphasic (type A) or deeply inverted (type B) T waves in leads V2–V3. It is typically caused by temporary obstruction of the left anterior descending (LAD) coronary artery due to the rupture of an atherosclerotic plaque leading to occlusion. Spontaneous coronary artery dissection (SCAD) is a rare cause of acute coronary syndrome and even a rarer cause of Wellens Syndrome. It occurs when an intramural hematoma forms, leading to the separation of the tunica intima from the outer layers and creating a false lumen that protrudes into the real lumen, ultimately reducing blood flow and thus resulting in myocardial infarction. Here we report a case of SCAD presenting as an acute coronary syndrome with self-resolving chest pain, slightly elevated myocardial necrosis markers and electrocardiographic changes consistent with Wellens pattern type A first, and type B afterwards, that were not present upon arrival to the emergency department.

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