Nature Communications (Jan 2018)
Double-layered protein nanoparticles induce broad protection against divergent influenza A viruses
Abstract
Relatively well conserved domains of influenza A virus (IAV) proteins are potential candidates for the development of a universal IAV vaccine. Here, Deng et al. combine two such conserved antigens (M2e and HA stalk) in a double-layered protein nanoparticle and show that it protects against divergent IAVs in mice.