Myosin-VIIa is expressed in multiple isoforms and essential for tensioning the hair cell mechanotransduction complex

Sihan Li; Andrew Mecca; Jeewoo Kim; Giusy A. Caprara; Elizabeth L. Wagner; Ting-Ting Du; Leonid Petrov; Wenhao Xu; Runjia Cui; Ivan T. Rebustini; Bechara Kachar; Anthony W. Peng; Jung-Bum Shin

doi:10.1038/s41467-020-15936-z

Nature Communications (Apr 2020)

Myosin-VIIa is expressed in multiple isoforms and essential for tensioning the hair cell mechanotransduction complex

Sihan Li,
Andrew Mecca,
Jeewoo Kim,
Giusy A. Caprara,
Elizabeth L. Wagner,
Ting-Ting Du,
Leonid Petrov,
Wenhao Xu,
Runjia Cui,
Ivan T. Rebustini,
Bechara Kachar,
Anthony W. Peng,
Jung-Bum Shin

Affiliations

Sihan Li: Department of Neuroscience, University of Virginia
Andrew Mecca: Department of Physiology and Biophysics, University of Colorado Anschutz Medical Campus
Jeewoo Kim: Department of Neuroscience, University of Virginia
Giusy A. Caprara: Department of Physiology and Biophysics, University of Colorado Anschutz Medical Campus
Elizabeth L. Wagner: Department of Neuroscience, University of Virginia
Ting-Ting Du: Department of Neuroscience, University of Virginia
Leonid Petrov: Department of Mathematics, University of Virginia
Wenhao Xu: Genetically Engineered Murine Model (GEMM) Core, University of Virginia
Runjia Cui: National Institute for Deafness and Communications Disorders, National Institute of Health
Ivan T. Rebustini: National Institute for Deafness and Communications Disorders, National Institute of Health
Bechara Kachar: National Institute for Deafness and Communications Disorders, National Institute of Health
Anthony W. Peng: Department of Physiology and Biophysics, University of Colorado Anschutz Medical Campus
Jung-Bum Shin: Department of Neuroscience, University of Virginia

DOI: https://doi.org/10.1038/s41467-020-15936-z
Journal volume & issue: Vol. 11, no. 1
pp. 1 – 15

Abstract

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How the ear achieves its remarkable sensitivity is still not fully understood. In this study, the authors demonstrate that the deafness protein myosin-VIIa and its isoforms are essential for tensioning the tip link, thereby sensitizing the auditory receptor cell’s mechanotransduction process.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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