Aspects of Point-of-Care Diagnostics for Personalized Health Wellness

Abstract

Sandeep Kumar,1 Monika Nehra,1 Sakina Khurana,1 Neeraj Dilbaghi,1 Vanish Kumar,2 Ajeet Kaushik,3 Ki-Hyun Kim4 1Department of Bio and Nano Technology, Guru Jambheshwar University of Science and Technology, Hisar, Haryana 125001, India; 2National Agri-Food Biotechnology Institute (NABI), Mohali, Punjab, India; 3NanoBioTech Laboratory, Department of Natural Sciences, Division of Sciences, Art, & Mathematics, Florida Polytechnic University, Lakeland, FL, 33805-8531, USA; 4Department of Civil & Environmental Engineering, Hanyang University, Seoul 04763, Republic of KoreaCorrespondence: Sandeep KumarDepartment of Bio and Nano Technology, Guru Jambheshwar University of Science and Technology, Hisar, Haryana 125001, IndiaEmail [email protected] KimDepartment of Civil & Environmental Engineering, Hanyang University, 222 Wangsimni-Ro, Seoul 04763, Republic of KoreaEmail [email protected]: Advancements in analytical diagnostic systems for point-of-care (POC) application have gained considerable attention because of their rapid operation at the site required to manage severe diseases, even in a personalized manner. The POC diagnostic devices offer easy operation, fast analytical outcome, and affordable cost, which promote their advanced research and versatile adoptability. Keeping advantages in view, considerable efforts are being made to design and develop smart sensing components such as miniaturized transduction, interdigitated electrodes-based sensing chips, selective detection at low level, portable packaging, and sustainable durability to promote POC diagnostics according to the needs of patient care. Such effective diagnostics systems are in demand, which creates the challenge to make them more efficient in every aspect to generate a desired bio-informatic needed for better health access and management. Keeping advantages and scope in view, this mini review focuses on practical scenarios associated with miniaturized analytical diagnostic devices at POC application for targeted disease diagnostics smartly and efficiently. Moreover, advancements in technologies, such as smartphone-based operation, paper-based sensing assays, and lab-on-a-chip (LOC) which made POC more sensitive, informative, and suitable for major infectious disease diagnosis, are the main focus here. Besides, POC diagnostics based on automated patient sample integration with a sensing platform is continuously improving therapeutics interventions against specific infectious disease. This review also discussed challenges associated with state-of-the-art technology along with future research opportunities to design and develop next generation POC diagnostic systems needed to manage infectious diseases in a personalized manner.Keywords: point-of-care devices, infectious diseases, lateral flow strips, microfluidics

Keywords

• point of care devices
• infectious diseases
• lateral flow strips
• microfluidics.